1. Fatty acid changes help to better understand regression of nonalcoholic fatty liver disease.
- Author
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Maciejewska D, Drozd A, Ossowski P, Ryterska K, Jamioł-Milc D, Banaszczak M, Raszeja-Wyszomirska J, Kaczorowska M, Sabinicz A, and Stachowska E
- Subjects
- Adult, Biomarkers blood, Blood Glucose metabolism, Dietary Fats blood, Docosahexaenoic Acids administration & dosage, Docosahexaenoic Acids blood, Eicosapentaenoic Acid administration & dosage, Eicosapentaenoic Acid blood, Fatty Acids blood, Fatty Acids, Monounsaturated administration & dosage, Fatty Acids, Monounsaturated blood, Fatty Acids, Unsaturated administration & dosage, Fatty Acids, Unsaturated blood, Female, Humans, Male, Middle Aged, Non-alcoholic Fatty Liver Disease blood, Non-alcoholic Fatty Liver Disease diagnosis, Non-alcoholic Fatty Liver Disease ethnology, Poland epidemiology, Prospective Studies, Remission Induction, Severity of Illness Index, Time Factors, Treatment Outcome, Weight Loss, White People, Young Adult, Dietary Fats administration & dosage, Fatty Acids administration & dosage, Non-alcoholic Fatty Liver Disease diet therapy
- Abstract
Aim: To investigate whether liver steatosis reduction due to a six-month dietary intervention results in significant changes in the concentrations of fatty acids., Methods: A group of 35 Caucasian individuals diagnosed with different levels of steatosis were prospectively enrolled in the present study. Analysis of the fatty acid profiles was performed according to changes in liver steatosis (liver steatosis reduction by one or two degrees) after a six-month dietary intervention. The diet helped reduce body mass in obese and overweight patients, and stabilize both glycemia and dyslipidemia. Fatty acids were extracted according to the Folch method and analyzed by gas chromatography., Results: This study showed significant changes in fatty acid profiles in patients who had reduced liver steatosis by one as well as two degrees. A reduction in liver steatosis by one degree caused a significant increase in the level of the n-3 family: eicosapentaenoic acid (P < 0.055), docosapentaenoic acid-C 22:5 (P < 0.05) and docosahexaenoic acid (P < 0.05). A reduction in liver steatosis by two degrees caused a significant decrease in serum palmitoleic acid-C 16:1 (P < 0.05)., Conclusion: Liver steatosis reduction is associated with changes in fatty acid profiles, and these changes may reflect an alteration in fatty acid synthesis and metabolism. These findings may help better understand regression of nonalcoholic fatty liver disease.
- Published
- 2015
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