1. Evaluation of Ficus retusa L. Leaves with Special Reference to Antidiarrheal and Anti-spasmodic Activity
- Author
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Najam Ali Khan, Chitra Tomar, Alankar Shrivastav, Arun K. Mishra, and Aftab Ahmad
- Subjects
biology ,Traditional medicine ,medicine.drug_class ,business.industry ,Ficus retusa ,Dose dependence ,biology.organism_classification ,Standard procedure ,Diarrhea ,Drug Discovery ,Antidiarrhoeal ,medicine ,Significant response ,Antispasmodic ,medicine.symptom ,business ,medicine.drug - Abstract
Aims: The aim of present investigation was to evaluate the traditional claim of Ficus retusa as an anti-diarrheal and anti-spasmodic agent using different pharmacological models. Background: Diarrhea is considered as major cause of mortality, especially in children and aged persons. Because of diarrhoea, 17% of admitted children get die. In order to treat the diarrhea, natural drugs may be useful. Objective: In order to prove the traditional claim of Ficus retusa, present work was undertaken with objective to prove antidiarrheal and antispasmodic activity. Methods: The anti-diarrhoeal activity was evaluated by magnesium sulphate induced diarrhea and 5-hydroxy tryptamine(5HT) induced diarrhea. Further, the exact were subjected to gastrointestinal motility test using standard procedure. Conclusion: The response towards bioactivity was dose dependent. It was concluded that 400mg/kg bw of ethanolic extract is most potent in antidiarrhoeal and antispasmodic activity.
- Published
- 2021
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