1. Laxative effects of partially defatted flaxseed meal on normal and experimental constipated mice
- Author
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Qingde Huang, Jiqu Xu, Nianhong Yang, Jine Yang, Qianchun Deng, Fenghong Huang, Xiaoqi Zhou, and Chang Chen
- Subjects
Dietary Fiber ,Male ,medicine.medical_specialty ,Constipation ,medicine.medical_treatment ,Laxative ,Mice, Inbred Strains ,Gastroenterology ,law.invention ,Feces ,Mice ,law ,Internal medicine ,Flax ,Intestine, Small ,medicine ,Animals ,Defecation ,Gastrointestinal Transit ,Diphenoxylate ,business.industry ,General Medicine ,lcsh:Other systems of medicine ,Dietary fibers ,Flaxseed ,lcsh:RZ201-999 ,Disease Models, Animal ,Complementary and alternative medicine ,Laxatives ,Dietary Supplements ,Seeds ,Stool frequency ,Plant Preparations ,medicine.symptom ,FLAXSEED MEAL ,Phytotherapy ,business ,medicine.drug ,Research Article - Abstract
Background Constipation is a very common health problem in the world. Intake of sufficient amount of dietary fibers is a cornerstone in the prevention and treatment of constipation. As a traditional medicine, flaxseed has been used to treat constipation for centuries, but the controlled trials are rare. The purpose of the present study was to assess that whether partially defatted flaxseed meal (PDFM) has the potential role to facilitate fecal output in normal and experimental constipated mice. Methods After supplemented with 2.5%, 5% and 10% (w/w) PDFM (L-, M- and H -PDFM) for 14 days, the constipation models of mice were induced by atropine-diphenoxylate. The small intestinal transit rates, start time of defecation, amount of defecation and wet weight of feces were researched in normal and constipation model mice. Results M- and H-PDFM significantly increase small intestinal transit rates in constipation model mice. All dose of PDFM markedly shortened the start time of defecation and M- and H-PDFM significantly increase stool frequency and weight in both normal and constipation model mice. Conclusions PDFM may be a useful laxative to facilitate fecal output in normal and constipation conditions.
- Published
- 2012