1. The 3D Genome as Moderator of Chromosomal Communication.
- Author
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Dekker, Job and Mirny, Leonid
- Subjects
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CHROMOSOMES , *GENE expression , *CELL communication , *CHROMATIN , *BIOPHYSICS , *CELL compartmentation , *GENOMES - Abstract
Proper expression of genes requires communication with their regulatory elements that can be located elsewhere along the chromosome. The physics of chromatin fibers imposes a range of constraints on such communication. The molecular and biophysical mechanisms by which chromosomal communication is established, or prevented, have become a topic of intense study, and important roles for the spatial organization of chromosomes are being discovered. Here we present a view of the interphase 3D genome characterized by extensive physical compartmentalization and insulation on the one hand and facilitated long-range interactions on the other. We propose the existence of topological machines dedicated to set up and to exploit a 3D genome organization to both promote and censor communication along and between chromosomes. [ABSTRACT FROM AUTHOR]
- Published
- 2016
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