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1. A MALDI-TOF Approach to Ubiquitin Ligase Activity.

Author

van Tol BDM, Geurink PP, and Ovaa H

Subjects
Drug Discovery, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization, Ubiquitination, Ubiquitin, Ubiquitin-Protein Ligases
Abstract

In this issue of Cell Chemical Biology,De Cesare et al. (2018) report the development of a high-throughput assay that measures E2/E3 enzyme activity by MALDI-TOF mass spectrometry and apply this to screen for small molecule E3 inhibitors. This assay potentially accelerates the drug discovery for the ubiquitin ligation pathway., (Copyright © 2018. Published by Elsevier Ltd.)

Published
2018
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