1. Protective role of salidroside against aging in a mouse model induced by D-galactose.
- Author
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Mao GX, Deng HB, Yuan LG, Li DD, Li YY, and Wang Z
- Subjects
- Aging, Premature blood, Aging, Premature chemically induced, Animals, Cerebral Cortex metabolism, Drugs, Chinese Herbal pharmacology, Galactose, Glial Fibrillary Acidic Protein, Glucosides pharmacology, Glycation End Products, Advanced blood, Interleukin-2 metabolism, Memory drug effects, Mice, Mice, Inbred C57BL, Motor Activity drug effects, Nerve Growth Factors metabolism, Nerve Tissue Proteins metabolism, Phenols pharmacology, Spleen drug effects, Spleen immunology, T-Lymphocytes drug effects, Aging, Premature prevention & control, Drugs, Chinese Herbal therapeutic use, Glucosides therapeutic use, Phenols therapeutic use
- Abstract
Objective: To investigate the protective effects of putative AGEs (advanced glycation endproducts) inhibitor salidroside against aging in an accelerated mouse aging model induced by D-galactose., Methods: A group of 5-month-old C57BL/6J mice were treated daily with D-galactose, D-galactose combined with salidroside, salidroside alone, and control buffer for 8 weeks. At the end of the treatment, serum AGEs levels, neurological activities, expression of glial fibrillary acidic protein (GFAP) and neurotrophin-3 (NT-3) in the cerebral cortex, as well as lymphocyte proliferation and IL-2 production were determined., Results: D-galactose induced mouse aging model was developed as described before. As expected, salidroside blocked D-galactose induced increase of serum AGEs levels. It also reversed D-galactose induced aging effects in neural and immune system, as evidenced by improving motor activity, increasing memory latency time, and enhancing lymphocyte mitogenesis and interleukin-2 (IL-2) production. Furthermore, elevated expression of GFAP and NT-3 in the aged model mice was also reduced upon salidroside treatment., Conclusion: Salidroside inhibits AGEs formation in vivo, which at least partially contributes to its anti-aging effect in D-galactose induced aging model.
- Published
- 2010
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