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Cerebro-metabolic disease is a recently proposed concept primarily referring to cerebrovascular injury caused by both traditional and residual metabolic risk factors. It represents a clinical syndrome in which intervention in metabolic risk factors can effectively improve the prognosis. Metabolic pathways do not exist independently. Various metabolic pathways in multiple organs such as the brain, heart, liver, kidneys, and intestines interact, collaborate, and intertwine to form the metabolic network of the human body. The abnormality in the metabolic network leads to the occurrence of cerebro-metabolic disease. Moreover, the presence of metabolic risk factors can simultaneously cause injury to multiple target organs, and the nervous system interacts with the cardiovascular system, endocrine system, digestive system, and others through various pathophysiological processes. Therefore, future research on cerebro-metabolic disease will gradually tend to multi-organ level in mechanism exploration and disease treatment, and develop into a multidisciplinary management approach. [ABSTRACT FROM AUTHOR]

Metabolic risk factors are important causes of cardiovascular and cerebrovascular diseases. There is already a definite concept and comprehensive management system for cardio-metabolic disease. While the incidence rate of stroke is higher and exhibit greater heterogeneity in China, and lacks a concept of cerebro-metabolic disease currently. Therefore, we reviewed the metabolic risk factors of stroke, proposed the concept and classification of cerebro-metabolic disease, elucidated the interdisciplinary and multi-organ level research methods based on multi-omics technology, introduced the characteristics of recently emerged metabolic drugs with cardiovascular benefits and the challenges and future directions. We aimed to provide a theoretical basis for the comprehensive management of cerebro-metabolic disease. [ABSTRACT FROM AUTHOR]