1. Effect of dietary pulse intake on established therapeutic lipid targets for cardiovascular risk reduction: a systematic review and meta-analysis of randomized controlled trials
- Author
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Ha, Vanessa, Sievenpiper, John L., de Souza, Russell J., Jayalath, Viranda H., Mirrahimi, Arash, Agarwal, Arnav, Chiavaroli, Laura, Mejia, Sonia Blanco, Sacks, Frank M., Di Buono, Marco, Bernstein, Adam M., Leiter, Lawrence A., Kris-Etherton, Penny M., Vuksan, Vladimir, Bazinet, Richard P., Josse, Robert G., Beyene, Joseph, Kendall, Cyril W.C., and Jenkins, David J.A.
- Subjects
Coca-Cola Co. (Atlanta, Georgia) ,Abbott Laboratories (Abbott Park, Illinois) ,Canada. Canadian Institutes of Health Research ,Calorie Control Council ,Canadian Diabetes Association ,World Health Organization ,Blood cholesterol -- Health aspects ,Soft drink industry -- Health aspects ,Trans fatty acids -- Health aspects ,Cardiovascular diseases -- Risk factors -- Health aspects ,Low density lipoproteins -- Health aspects ,Pharmaceutical industry -- Health aspects ,Health ,Risk factors ,Health aspects - Abstract
Background: Evidence from controlled trials encourages the intake of dietary pulses (beans, chickpeas, lentils and peas) as a method of improving dyslipidemia, but heart health guidelines have stopped short of ascribing specific benefits to this type of intervention or have graded the beneficial evidence as low. We conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) to assess the effect of dietary pulse intake on established therapeutic lipid targets for cardiovascular risk reduction. Methods: We searched electronic databases and bibliographies of selected trials for relevant articles published through Feb. 5, 2014. We included RCTs of at least 3 weeks' duration that compared a diet emphasizing dietary pulse intake with an isocaloric diet that did not include dietary pulses. The lipid targets investigated were low-density lipopro tein (LDL) cholesterol, apolipoprotein B and non-high-density lipoprotein (non-HDL) cholesterol. We pooled data using a randomeffects model. Results: We identified 26 RCTs (n = 1037) that satisfied the inclusion criteria. Diets emphasizing dietary pulse intake at a median dose of 130 g/d (about 1 serving daily) significantly lowered LDL cholesterol levels compared with the control diets (mean difference -0.17mmol/L, 95% confidence interval -0.25 to -0.09 mmol/L). Treatment effects on apolipoprotein B and non-HDL cholesterol were not observed. Interpretation: Our findings suggest that dietary pulse intake significantly reduces LDL cholesterol levels. Trials of longer duration and higher quality are needed to verify these results. Trial registration: ClinicalTrials.gov, no. NCT01594567., Abnormal blood concentrations of lipids are one of the most important modifiable risk factors for cardiovascular disease. Although statins are effective in reducing low-density lipoprotein (LDL) cholesterol levels, major health [...]
- Published
- 2014
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