1. Sleep is required for odor exposure to consolidate memory and remodel olfactory synapses
- Author
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Rashmi Chandra, Fatima Farah, Fernando Muñoz-Lobato, Anirudh Bokka, Kelli L. Benedetti, Chantal Brueggemann, Fatema Saifuddin, Julia M. Miller, Joy Li, Eric Chang, Aruna Varshney, Vanessa Jimenez, Anjana Baradwaj, Cibelle Nassif, Sara Alladin, Kristine Andersen, Angel J. Garcia, Veronica Bi, Sarah K. Nordquist, Raymond L. Dunn, Kateryna Tokalenko, Emily Soohoo, Vanessa Garcia, Sukhdeep Kaur, Malcolm Harris, Fabiola Briseno, Brandon Fung, Andrew Bykov, Hazel Guillen, Decklin Byrd, Emma Odisho, Bryan Tsujimoto, Alan Tran, Alex Duong, Kevin C. Daigle, Rebekka Paisner, Carlos E. Zuazo, Matthew A. Churgin, Christopher Fang-Yen, Martina Bremer, Saul Kato, Noëlle D. L’Étoile, and Miri K. VanHoven
- Subjects
medicine.anatomical_structure ,Odor ,Interneuron ,Period (gene) ,medicine ,Memory consolidation ,Neuron ,Biology ,Inhibitory postsynaptic potential ,Neuroscience ,Sleep in non-human animals - Abstract
SUMMARYAnimals with complex nervous systems demand sleep for memory consolidation and synaptic remodeling. Here we show that though theCaenorhabditis elegansnervous system has a limited number of neurons, sleep is necessary for both processes. In addition, it is unclear in any system if sleep collaborates with experience to alter synapses between specific neurons and whether this ultimately affects behavior.C. elegansneurons have defined connections and well-described contributions to behavior. We show that spaced odor-training and post-training sleep induce long-term memory. Memory consolidation, but not acquisition, requires a pair of interneurons, the AIYs, which play a role in odor-seeking behavior. In worms that consolidate memory, both sleep and odor conditioning are required to diminish inhibitory synaptic connections between the AWC chemosensory neurons and the AIYs. Thus, we demonstrate in a living organism that sleep is required for events immediately after training that drive memory consolidation and alter synaptic structures.
- Published
- 2020
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