1. A distinct cardiopharyngeal mesoderm genetic hierarchy establishes antero-posterior patterning of esophagus striated muscle
- Author
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Francesca Pala, Shahragim Tajbakhsh, Francina Langa, Glenda Comai, Gabrielle Kardon, Sebastian Mella, Sylvain Paisant, Eglantine Heude, Swetha Gopalakrishnan, Mirialys Gallardo, Cellules Souches et Développement / Stem Cells and Development, Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), Département Adaptations du vivant (AVIV), Muséum national d'Histoire naturelle (MNHN), Laboratory of Clinical Immunology and Microbiology [Bethesda, MA, USA] (LCIM), National Institute of Allergy and Infectious Diseases [Bethesda] (NIAID-NIH), National Institutes of Health [Bethesda] (NIH)-National Institutes of Health [Bethesda] (NIH), Department of Human Genetics [Salt Lake City, UT, USA], University of Utah, Centre d'Ingénierie génétique murine - Mouse Genetics Engineering Center (CIGM), Institut Pasteur [Paris], HiLIFE - Neuroscience Center (NC), Helsinki Institute of Life Science (HiLIFE), University of Helsinki-University of Helsinki, We acknowledge funding support from the Institut Pasteur, Association Franc¸ aise contre le Myopathies, Agence Nationale de la Recherche (Laboratoire d’Excellence Revive, Investissement d’Avenir, ANR-10-LABX-73)., ANR-10-LABX-0073,REVIVE,Stem Cells in Regenerative Biology and Medicine(2010), Heude, Eglantine, Laboratoires d'excellence - Stem Cells in Regenerative Biology and Medicine - - REVIVE2010 - ANR-10-LABX-0073 - LABX - VALID, Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), Physiologie moléculaire et adaptation (PhyMA), Muséum national d'Histoire naturelle (MNHN)-Centre National de la Recherche Scientifique (CNRS), Institut Pasteur [Paris] (IP), Helsingin yliopisto = Helsingfors universitet = University of Helsinki-Helsingin yliopisto = Helsingfors universitet = University of Helsinki, Centre of Excellence in Stem Cell Metabolism, and Institute of Biotechnology
- Subjects
Mouse ,Tbx1-Isl1-Met/HGF ,[SDV.BBM.BM] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology ,Mesoderm ,Mice ,0302 clinical medicine ,SKELETAL MYOGENESIS ,Biology (General) ,[SDV.BDD]Life Sciences [q-bio]/Development Biology ,0303 health sciences ,Hepatocyte Growth Factor ,Myogenesis ,General Neuroscience ,C-MET RECEPTOR ,1184 Genetics, developmental biology, physiology ,Gene Expression Regulation, Developmental ,General Medicine ,Proto-Oncogene Proteins c-met ,Cell biology ,DIFFERENTIATION ,medicine.anatomical_structure ,Medicine ,MOUSE ESOPHAGUS ,Signal Transduction ,Research Article ,EXPRESSION ,TBX1 ,GROWTH-FACTOR ,QH301-705.5 ,PHARYNGEAL ARCH ,Science ,LIM-Homeodomain Proteins ,Biology ,General Biochemistry, Genetics and Molecular Biology ,03 medical and health sciences ,Esophagus ,REVEALS ,[SDV.BDD] Life Sciences [q-bio]/Development Biology ,myogenic migration ,medicine ,Animals ,HEAD ,Body Patterning ,030304 developmental biology ,Progenitor ,Evolutionary Biology ,General Immunology and Microbiology ,antero-posterior patterning ,cardiopharyngeal mesoderm ,Skeletal muscle ,[SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology ,Muscle, Striated ,PROGENITOR CELLS ,esophagus striated muscles ,ISL1 ,T-Box Domain Proteins ,030217 neurology & neurosurgery ,Pharyngeal arch ,Transcription Factors ,Developmental Biology - Abstract
International audience; In most vertebrates, the upper digestive tract is composed of muscularized jaws linked to the esophagus that permits food ingestion and swallowing. Masticatory and esophagus striated muscles (ESM) share a common cardiopharyngeal mesoderm (CPM) origin, however ESM are unusual among striated muscles as they are established in the absence of a primary skeletal muscle scaffold. Using mouse chimeras, we show that the transcription factors Tbx1 and Isl1 are required cell-autonomously for myogenic specification of ESM progenitors. Further, genetic loss-of-function and pharmacological studies point to MET/HGF signaling for antero-posterior migration of esophagus muscle progenitors, where Hgf ligand is expressed in adjacent smooth muscle cells. These observations highlight the functional relevance of a smooth and striated muscle progenitor dialogue for ESM patterning. Our findings establish a Tbx1-Isl1-Met genetic hierarchy that uniquely regulates esophagus myogenesis and identify distinct genetic signatures that can be used as framework to interpret pathologies arising within CPM derivatives.
- Published
- 2019