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1. Retinoblastoma with and without Extraocular Tumor Extension

Author

Swathi Kaliki, MD, Vijitha S. Vempuluru, MD, Ido Didi Fabian, MD, Elhassan Abdallah, MD, Shehu U. Abdullahi, MD, Rula A. Abdulqader, MD, Aminatu A. Abdulrahaman, MD, Sherif Abouelnaga, MD, Dupe S. Ademola-Popoola, FMCOph, FWACS, Adedayo Adio, FWACS, Mahmoud A. Afifi, MD, Armin R. Afshar, MD, Priyanka Aggarwal, MD, Ada E. Aghaji, FMCOph MSc, Alia Ahmad, MRCPCH UK, Marliyanti N.R. Akib, MD, Adeseye M. Akinsete, MBBS, Lamis Al Harby, MD, Saleh A. Al Mesfer, MD, Mouroge H. Al Ani, MD, Silvia Alarcón Portabella, MD, Safaa A.F. Al-Badri, MD, Ana Patricia A. Alcasabas, MD, Saad A. Al-Dahmash, MD, Amanda Alejos, MD, Ernesto Alemany-Rubio, MD, Amadou I. Alfa Bio, MD, Yvania Alfonso Carreras, MD, Christiane E. Al-Haddad, MD, Hamoud H.Y. Al-Hussaini, MD, MSc, Amany M. Ali, MD, Donjeta B. Alia, MD, Mazin F. Al-Jadiry, MD, Usama Al-Jumaly, MD, Hind M. Alkatan, MD, Charlotta All-Eriksson, MD, PhD, Ali A.R.M. Al-Mafrachi, FIBMS, Argentino A. Almeida, MD, Khalifa M. Alsawidi, MD, Athar A.S.M. Al-Shaheen, MD, Entissar H. Al-Shammary, MD, Doreen Amankwaa-Frempong, MBChB, Primawita O. Amiruddin, MD, Inggar Armytasari, MD, Nicholas J. Astbury, FRCS, FRCOphth, Hatice T. Atalay, MD, Eda Ataseven, MD, La-ongsri Atchaneeyasakul, MD, Rose Atsiaya, OCO, Rudolf Autrata, MD, PhD, Julia Balaguer, MD, PhD, Ruhengiz Balayeva, PhD, Honorio Barranco, MD, PhD, Paulina Bartoszek, MD, Katarina Bartuma, MD, PhD, Covadonga Bascaran, MD, MSc, Nikolaos E. Bechrakis, MD, Maja Beck Popovic, MD, Ainura S. Begimkulova, MD, Sarra Benmiloud, MD, Rokia C. Berete, MD, PhD, Jesse L. Berry, MD, Anirban Bhaduri, MD, Sunil Bhat, MBBS, MD, Arpita Bhattacharyya, MD, Eva M. Biewald, MD, Elaine Binkley, MD, Sharon Blum, MD, Nadia Bobrova, MD, H. Culver Boldt, MD, Maria Teresa B.C. Bonanomi, MD, PhD, Gabrielle C. Bouda, MD, Hédi Bouguila, MD, PhD, Rachel C. Brennan, MD, Bénédicte G. Brichard, MD, PhD, Jassada Buaboonnam, MD, Aléine Budiongo, MD, Matthew Burton, FRCOphth, Patricia Calderón-Sotelo, MD, Doris A. Calle Jara, MD, Jayne E. Camuglia, FRANZCO, Miriam R. Cano, MD, MSc, Michael Capra, FRCPI, Shani Caspi, MD, Nathalie Cassoux, MD, PhD, Guilherme Castela, MD, Luis Castillo, MD, Jaume Català-Mora, MD, PhD, Isabel Caviedes, MD, Arthika Chandramohan, MD, Guillermo L. Chantada, MD, PhD, Shabana Chaudhry, MD, Bhavna Chawla, MD, Wensi Chen, MD, Faraja S. Chiwanga, MSc, Tsengelmaa Chuluunbat, MD, PhD, Krzysztof Cieslik, MD, Antony Clark, FRANZCO, Ruellyn L. Cockcroft, MB ChB , M Med Paed, Codruta Comsa, MD, Maria G. Correa Llano, MD, Timothy W. Corson, PhD, Line Couitchere, MD, Kristin E. Cowan-Lyn, MD, MBBS, Monika Csóka, MD, PhD, Wantanee Dangboon, MD, Anirban Das, MD, Pranab Das, MD, Sima Das, MS, Jacquelyn M. Davanzo, BSN, BSPH, Alan Davidson, MBChB, MPhil, Sonia De Francesco, MD, Patrick De Potter, MD, PhD, Karina Q. Delgado, MD, PhD, Hakan Demirci, MD, Laurence Desjardins, MD, Rosdali Y. Diaz Coronado, MD, Helen Dimaras, PhD, Andrew J. Dodgshun, M Phil, Carla R. Donato Macedo, MD, Monica D. Dragomir, MD, PhD, Yi Du, MD, Magritha Du Bruyn, MD, Johannes P. Du Plessis, MMed (Paed), Gagan Dudeja, MBBS, MS, Katrin Eerme, MD, I Wayan Eka Sutyawan, MD, Asmaa El Kettani, MD, Amal M. Elbahi, MD, James E. Elder, MBBS, Alaa M. Elhaddad, MD, PhD, Moawia M.A. Elhassan, MD, Mahmoud M. Elzembely, MD, Connor Ericksen, MD, Vera A. Essuman, FWACS, Ted Grimbert A. Evina, MD, Ifeoma R. Ezegwui, FMCOph, FWACS, FAEH, Zehra Fadoo, MBBS, Adriana C. Fandiño, MD, Mohammad Faranoush, MD, Oluyemi Fasina, FWACS, Delia D.P.G. Fernández, MSc, Ana Fernández-Teijeiro, MD, PhD, Allen Foster, FRCOphth, Shahar Frenkel, MD, PhD, Ligia D. Fu, MD, Soad L. Fuentes-Alabi, MD, MPH, Juan L. Garcia, MSc, David García Aldana, MD, Henry N. Garcia Pacheco, MD, Jennifer A. Geel, MBChB, MMed, Fariba Ghassemi, MD, Ana V. Girón, MD, Marco A. Goenz, MD, Aaron S. Gold, OD, Hila Golberg, MD, Glen A. Gole, MD, FRANZCO, Nir Gomel, MD, Efren Gonzalez, MD, Graciela Gonzalez Perez, MD, Liudmira González-Rodríguez, MD, Malka Gorfine, PhD, Jaime Graells, MD, Pernille A. Gregersen, MD, Nathalia D.A.K. Grigorovski, MD, Koffi M. Guedenon, MD, D Sanjeeva Gunasekera, MD, Ahmet K. Gündüz, MD, Himika Gupta, MD, Sanjiv Gupta, MS, Vineeta Gupta, MD, Theodora Hadjistilianou, MD, Patrick Hamel, MD, Syed A. Hamid, FCPS, Norhafizah Hamzah, MSc, Eric D. Hansen, MD, J William Harbour, MD, M. Elizabeth Hartnett, MD, Murat Hasanreisoglu, MD, Sadiq Hassan, MD, FWACS, Shadab Hassan, FRCS, FCPS, Wojciech Hautz, MD, Huda A. Haydar, CHD, Stanislava Hederova, MD, Laila Hessissen, MD, Hoby Lalaina, MD, Suradej Hongeng, MD, Diriba F. Hordofa, MD, G. Baker Hubbard, MD, Marlies Hummlen, MD, Kristina Husakova, MD, Allawi N. Hussein Al-Janabi, MD, Affiong A. Ibanga, MB.BCh, FMCOph, Russo Ida, MD, Vesna R. Ilic, MD, Ziyavuddin Islamov, MD, Vivekaraj Jairaj, DNB, Teyyeb A. Janjua, MD, FCPS, FRCSEd, Irfan Jeeva, FRCOphth, Xunda Ji, MD, Dong Hyun Jo, MD, PhD, Michael M. Jones, MD, PhD, FRANZCO, Theophile B. Amani Kabesha, MD, PhD, Rolande L. Kabore, MD, Abubakar Kalinaki, MD, Pius Kamsang, MD, Mehmet Kantar, MD, Noa Kapelushnik, MD, Tamar Kardava, PhD, Rejin Kebudi, MD, Jonny Keomisy, MD, Tomas Kepak, MD, Petra Ketteler, MD, Zohora J. Khan, MD, Hussain A. Khaqan, MD, Vikas Khetan, FRCS, FACS, Alireza Khodabande, MD, Zaza Khotenashvili, MD, Jonathan W. Kim, MD, Jeong Hun Kim, MD, PhD, Hayyam Kiratli, MD, Tero T. Kivelä, MD, Artur Klett, MD, PhD, Irem Koç, MD, Jess Elio Kosh Komba Palet, MD, Dalia Krivaitiene, MD, PhD, Mariana Kruger, Mmed Paed, PhD, Kittisak Kulvichit, MD, Mayasari W. Kuntorini, MD, Alice Kyara, BA, Geoffrey C. Lam, FRANZCO, Scott A. Larson, MD, Slobodanka Latinović, MD, PhD, Kelly D. Laurenti, MD, Yotam Lavi, MD, PhD, Alenka Lavric Groznik, MD, Amy A. Leverant, MD, Cairui Li, MD, Kaijun Li, MD, Ben Limbu, MD, Chun-Hsiu Liu, MD, Quah Boon Long, FRCS (Ed), MMed ( Ophth), FAMS, Juan P. López, MD, Robert M. Lukamba, MD, Sandra Luna-Fineman, MD, Delfitri Lutfi, MD, Lesia Lysytsia, MD, Shiran Madgar, MD, George N. Magrath, MD, Amita Mahajan, MD, Puja Maitra, MD, Erika Maka, MD, Emil K. Makimbetov, MD, Azza M.Y. Maktabi, MD, Carlos Maldonado, MD, Ashwin Mallipatna, MD, Rebecca Manudhane, MD, Lyazat Manzhuova, MD, Nieves Martín Begue, MD, PhD, Sidra Masud, MBBS, Ibrahim O. Matende, MD, M. Med (Oph), Clarissa C.D.S. Mattosinho, MD, Marchelo Matua, BAPH, Ismail Mayet, MD, Freddy B. Mbumba, MD, MMed Paed, John D. McKenzie, MD, Azim Mehrvar, MD, Aemero A. Mengesha, MD, Vikas Menon, MD, Gary John V.D.D. Mercado, MD, Marilyn B. Mets, MD, Edoardo Midena, MD, PhD, Audra Miller, MD, Divyansh K.C. Mishra, DNB, Furahini G. Mndeme, MD, Ahmed A. Mohamedani, FRCPath, Mona T. Mohammad, MD, FRCS, Annette C. Moll, MD, PhD, Margarita M. Montero, MD, Claude Moreira, MD, PhD, Prithvi Mruthyunjaya, MD, MHS, Mchikirwa S. Msina, MMed Ophth, Gerald Msukwa, MMed Ophth, Sangeeta S. Mudaliar, DNB Pediatric, Hassan Muhammad, MD, Kangwa I. Muma, MMed Ophth, FCOphth, Francis L. Munier, MD, Timothy G. Murray, MD, MBA, Kareem O. Musa, FWACS, FMCOphth, FICO, Asma Mushtaq, MD, Anne A. Musika, MD, Hamzah Mustak, MD, Tajudeen Mustapha, MBBS, FWACS, Okwen M. Muyen, MD, Khumo H. Myezo, Msc, Gita Naidu, MMed Paed, PhD, Natasha Naidu, MBCHB, FCS Ophthalmol, Akshay Gopinathan Nair, MD, Sundaram Natarajan, FRCS, Larisa Naumenko, MD, PhD, Paule Aïda Ndoye Roth, MD PhD, Yetty M. Nency, MD, Vladimir Neroev, MD, PhD, Yvonne Ng, MBChB ( Auckland) , FRANZCO, Marina Nikitovic, MD, PhD, Elizabeth D. Nkanga, FMCOph, Henry E. Nkumbe, MD, Marcel N. Numbi, MD, Kalle Nummi, MD, Murtuza Nuruddin, FRCS, Mutale Nyaywa, MD, MMed Ophth, FCOphth, Chinsisi Nyirenda, MD, Ghislaine Obono-Obiang, MD, Scott C.N. Oliver, MD, Joaquin Ooporto, MD, Miriam Ortega-Hernández, MD, Alexander Oscar, MD, Diego Ossandon, MD, Halimah Pagarra, MD, PhD, Vivian Paintsil, FWACP, Luisa Paiva, MD, Mahesh Shanmugam Palanivelu, FRCSED, Ruzanna Papyan, MD, Raffaele Parrozzani, MD, PhD, Claudia R. Pascual Morales, MD, Katherine E. Paton, MD, FRCSC, Jacob Pe'er, MD, Jesús Peralta Calvo, MD, Sanja Perić, MD, PhD, Chau T.M. Pham, MD, Remezo Philbert, MD, David A. Plager, MD, Pavel Pochop, MD, PhD, Rodrigo A. Polania, MD, Vladimir Polyakov, MD, Jimena Ponce, MD, Ali O. Qadir, MD, Seema Qayyum, FCPS, Jiang Qian, MD, Ardizal Rahman, MD, Purnima Rajkarnikar, MD, Rajesh Ramanjulu, MD, Aparna Ramasubramanian, MD, Marco A. Ramirez-Ortiz, MD, MPH, Jasmeen K. Randhawa, BA, Léa Raobela, MD, Riffat Rashid, MS, M. Ashwin Reddy, FRCOphth, Lorna A. Renner, FRCPCH (UK), David Reynders, MD, Dahiru Ribadu, FMCOph, Petra Ritter-Sovinz, MD, Anna Rogowska, MD, Duangnate Rojanaporn, MD, Livia Romero, MD, Soma R. Roy, DCO, Raya H. Saab, MD, Svetlana Saakyan, MD, PhD, Ahmed H. Sabhan, MD, Mandeep S. Sagoo, FRCS (Ed), Azza M.A. Said, MD, Rohit Saiju, MD, Beatriz Salas, MD, Sonsoles San Román Pacheco, MD, Gissela L. Sánchez, MD, Alma Janeth Sanchez Orozco, MD, Phayvanh Sayalith, MD, Trish A. Scanlan, MRCPI, MSc, Christoph Schwab, MD, Ahad Sedaghat, MD, Rachna Seth, DNB MNAMS, Mariana Sgroi, MD, Ankoor S. Shah, MD, PhD, Shawkat A. Shakoor, MS, Manoj K. Sharma, MD, Sadik T. Sherief, MD, Carol L. Shields, MD, David Sia, MB ChB, FRANZCO, Sorath Noorani Siddiqui, MD, Sidi Sidi cheikh, MD, PhD, Sónia Silva, MD, Arun D. Singh, MD, Usha Singh, MS, Penny Singha, MD, Rita S. Sitorus, MD, PhD, Alison H. Skalet, MD, PhD, Hendrian D. Soebagjo, MD, PhD, Tetyana Sorochynska, MD, PhD, Grace Ssali, MD, Andrew W. Stacey, MD, Sandra E. Staffieri, PhD, Erin D. Stahl, MD, David M. Steinberg, PhD, David K. Stones, MBChB, FCPaed, Caron Strahlendorf, MD, Maria Estela Coleoni Suarez, MD, Sadia Sultana, FCPS, Xiantao Sun, MD, Rosanne Superstein, MD, Eddy Supriyadi, MD, PhD, Supawan Surukrattanaskul, MD, Shigenobu Suzuki, MD, PhD, Karel Svojgr, MD, PhD, Fatoumata Sylla, MD, Gevorg Tamamyan, MD, PhD, Deborah Tan, MBBS, Alketa Tandili, MD, PhD, Jing Tang, MD, Fanny F. Tarrillo Leiva, MD, Maryam Tashvighi, MD, Bekim Tateshi, MD, PhD, Kok Hoi Teh, MD, Edi S. Tehuteru, MD, Luiz F. Teixeira, MD, Manca Tekavcic Pompe, MD, PhD, Abdullah Dahan M. Thawaba, MD, Tuyisabe Theophile, MSc, Helen Toledano, MBChB, Doan L. Trang, MD, Fousseyni Traoré, MD, Devjyoti Tripathy, MD, Samuray Tuncer, MD, Harba Tyau-Tyau, MD, Ali B. Umar, MD, FMCPath, Emel Unal, MD, Ogul E. Uner, BA, Steen F. Urbak, MD, PhD, Tatiana L. Ushakova, MD, Rustam H. Usmanov, MD, Sandra Valeina, MD, Paola Valente, MD, Milo van Hoefen Wijsard, MD, Jacqueline Karina Vasquez Anchaya, MD, Leon O. Vaughan, FRCS (Ed), Nevyana V. Veleva-Krasteva, MD, PhD, Nishant Verma, MD, Andi A. Victor, MD, PhD, Maris Viksnins, MD, Edwin G. Villacís Chafla, MD, Victor M. Villegas, MD, Victoria Vishnevskia-Dai, MD, Keith Waddell, DM, FRCP, FRCS, FRCOphth, Amina H. Wali, MD, FMCOph Nigeria, Yi-Zhuo Wang, MD, Nutsuchar Wangtiraumnuay, MD, FICO, Julie A. Wetter, MMed Rad Onc, FCRad Onc, Widiarti P. Riono, MD, Matthew W. Wilson, MD, Amelia D.C. Wime, MD, Atchareeya Wiwatwongwana, MD, Damrong Wiwatwongwana, MD, Charlotte Wolley Dod, MD, Emily S. Wong, FCOphth HK, FHKAM, Phanthipha Wongwai, MD, PhD, Si-qi Wu, MSc, Daoman Xiang, MD, PhD, Yishuang Xiao, MSc, Bing Xu, MD, Kang Xue, MD, Antonio Yaghy, MD, Jason C. Yam, FRCSEd, Huasheng Yang, MD, Jenny M. Yanga, MD, Muhammad A. Yaqub, MD, FCPS, FRCSEd, Vera A. Yarovaya, MD, Andrey A. Yarovoy, MD, PhD, Huijing Ye, MD, Roberto I. Yee, MD, Yacoub A. Yousef, MD, Putu Yuliawati, MD, Arturo M. López, MD, Ekhtelbenina Zein, MD, Yi Zhang, MD, PhD, Katsiaryna Zhilyaeva, MD, Nida Zia, MBBS, MCPS, Othman A.O. Ziko, MD, PhD, Marcia Zondervan, MBA, Sabrina Schlüter, MD, and Richard Bowman, FRCOphth

Subjects
External beam radiotherapy, Extraocular extension, Multimodal treatment, Retinoblastoma, Tumor, Ophthalmology, RE1-994
Abstract

Purpose: To study the treatment and outcomes of children with retinoblastoma (RB) with extraocular tumor extension (RB-EOE) and compare them with RB without extraocular tumor extension (RB-w/o-EOE). Design: Multicenter intercontinental collaborative prospective study from 2017 to 2020. RB-EOE cases included those with overt orbital tumor extension in treatment-naive patients. Cases with microscopic orbital extension detected postenucleation were excluded from the study. Participants: A total of 319 children with RB-EOE and 3116 children with RB-w/o-EOE. Intervention: Chemotherapy, enucleation, exenteration, radiotherapy. Main Outcome Measures: Systemic metastasis and death. Results: Of the 3435 RB patients included in this study, 309 (9%) were from low-income countries (LIC), 1448 (42%) from lower-middle income, 1012 (29%) from upper-middle income, and 666 (19%) patients from high-income countries. There was an inverse relationship between the percentage of RB-EOE and national income level, with 96 (31%) patients from LIC, 197 (6%) lower-middle income, 20 (2%) upper-middle income, and 6 (1%) patients from high-income countries (P = 0.0001). The outcomes were statistically significant for RB-EOE compared with RB-w/o-EOE: systemic metastasis (32% vs. 4% respectively; P = 0.0001) and metastasis-related death (63% vs. 6% respectively; P = 0.0001). Multimodal treatment was the most common form of treatment (n = 177; 54%) for RB-EOE, with most cases undergoing a combination of intravenous chemotherapy and enucleation (n = 97; 30%). Adjuvant external beam radiotherapy (EBRT) after surgery (enucleation/orbital exenteration) was given in only 68 (21%) cases. Kaplan–Meier analysis for systemic metastasis and metastasis-related death in RB-EOE was 28% and 57% at 1 year, 29% and 60% at 2 years, and 29% and 61% at 3 years, respectively. Cox regression analysis revealed that the risk of death from RB-EOE was greater in patients aged >4 years than

Published
2025
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2. Evaluation of the ICD-10 system in coding revascularisation procedures in patients with peripheral arterial disease in England: A retrospective cohort study using national administrative and clinical databasesResearch in context

Author

Panagiota Birmpili, Eleanor Atkins, Qiuju Li, Amundeep S. Johal, Sam Waton, Robin Williams, Arun D. Pherwani, and David A. Cromwell

Subjects
Clinical coding, Electronic health records, Registries, Peripheral arterial disease, Vascular surgical procedures, Hospital episode statistics, Medicine (General), R5-920
Abstract

Summary: Background: Many studies evaluating care in hospitals in England use the Hospital Episode Statistics (HES) administrative database. The aim of this study was to explore whether the International Classification of Diseases 10th Revision (ICD-10) system used by HES supported the evaluation of care received by patients with peripheral arterial disease (PAD) who had revascularisation. Methods: This retrospective cohort study used records on patients who had revascularisation for PAD between 1st January 2017 and 31st December 2019 in England, collected prospectively in the National Vascular Registry (NVR) and linked to HES. Patients were excluded if their NVR record did not have a match in HES, due to lack of consent or different admission and procedure dates. Agreement between different presentations of PAD recorded in the NVR and the ICD-10 diagnostic codes recorded in HES was evaluated using the unweighted Kappa statistic and sensitivity and specificity. Agreement between the NVR and HES was also assessed for gender, age, comorbidities, mode of admission, and procedure type and side. Findings: In total, 20,603 patients who had 24,621 admissions were included in the study. Agreement between NVR and HES on patient gender (Kappa = 0.98), age (Kappa = 0.98), mode of admission (Kappa = 0.80), and procedure type and side (Kappa = 0.92 and 0.87, respectively) was excellent. When all diagnostic fields in HES were explored, substantial agreement was observed for chronic ischaemia with tissue loss (Kappa = 0.63), but it was lower for chronic ischaemia without tissue loss (Kappa = 0.32) and acute limb ischaemia (Kappa = 0.15). Agreement on comorbidities was mixed; excellent for diabetes (Kappa = 0.82), moderate for chronic lung disease (Kappa = 0.56), chronic kidney disease (Kappa = 0.56), and ischaemic heart disease (Kappa = 0.45) and fair for chronic heart failure (Kappa = 0.35). Interpretation: The diagnostic ICD-10 codes currently used in HES cannot accurately differentiate between stages of PAD. Therefore, studies using HES to examine patterns of care and outcomes for patients with PAD are likely to suffer from misclassification bias. Adopting an extended ICD-10 system or the ICD-11 version released to the World Health Organisation member states in 2022, may overcome this problem. Funding: Healthcare Quality Improvement Partnership (HQIP).

Published
2023
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3. Rapid symptomatic and structural improvement of a retinal astrocytic hamartoma in response to anti-VEGF therapy: A case report

Author

Kevin C. Allan, Hong-Uyen Hua, Arun D. Singh, and Alex Yuan

Subjects
Retinal astrocytic hamartoma, Retinal astrocytoma, Anti-VEGF, Subretinal fluid, Tuberous sclerosis, Neurofibromatosis, Ophthalmology, RE1-994
Abstract

Purpose: To describe a patient with bilateral peripapillary astrocytic hamartomas with exudation of subretinal fluid into the macula and loss of vision without evidence of choroidal neovascularization. The patient rapidly responded to intravitreal bevacizumab injections resulting in reduced subretinal fluid and clinical improvement. Observation: A 70-year-old female presented with worsening vision in her left eye due to subretinal fluid exudation from a peripapillary astrocytic hamartoma. The patient was treated with two doses of bevacizumab with rapid improvement in vision and resolution of subretinal fluid. Genetic testing was negative for common pathogenic variants for tuberous sclerosis and neurofibromatosis, which are highly associated with bilateral optic nerve and retinal astrocytic hamartomas. Conclusion: Astrocytic hamartomas with exudation may be responsive to bevacizumab suggesting a dependence of these lesions on vascular endothelial growth factor (VEGF) independent of secondary choroidal neovascularization. Furthermore, this case describes a patient with bilateral astrocytic hamartomas without genetic or clinical confirmation of associated phakomatoses, such as tuberous sclerosis and neurofibromatosis.

Published
2022
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5. Conjunctival squamous papilloma refractory to interferon α-2b in a patient on systemic immunosuppression (tacrolimus)

Author

Preethi S. Ganapathy, Thomas Plesec, and Arun D. Singh

Subjects
Tacrolimus, Papilloma, Conjunctiva, Interferon α-2b, Mitomycin c, Ophthalmology, RE1-994
Abstract

Purpose: To describe a case of diffuse conjunctival papilloma in an immunocompromised individual on tacrolimus that was refractory to treatment with interferon α-2b, but responded to topical mitomycin-c. Observations: A 79-year-old Caucasian female with a history of a liver transplant twenty years ago, who was immunosuppressed with tacrolimus (2 mg daily) presented with a diffuse conjunctival and corneal squamous papilloma. Following treatment with four weekly subconjunctival interferon-α2b injections (3 million units/0.5 mL) and 3 months of topical interferon-α2b therapy (1 million units/mL), four times daily, slow progression was documented. The patient was switched to topical mitomycin-c drops (0.04%) administered four times daily (one week on and one week off) with dramatic regression of the tumor. Conclusion: and Importance. In cases of conjunctival squamous papilloma that do not respond readily to topical interferon, topical mitomycin-c is an alternate therapeutic option. We hypothesize that use of tacrolimus may have contributed to the lack of response to topical interferon-α2b.

Published
2017
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6. Contributors

Author

Ahmed, Omar H., primary, Ansari, Shaheryar F., additional, Arko, Leopold, additional, Banks, Catherine, additional, Barkhoudarian, Garni, additional, Biglioli, Federico, additional, Bleier, Benjamin S., additional, Boahene, Kofi, additional, Borghei-Ravazi, Hamid, additional, Cappello, Zachary J., additional, Carniciu, Anais L., additional, Carrau, Ricardo L., additional, Cassidy, Matthew, additional, Chandra, Rakesh, additional, Chitguppi, Chandala, additional, Chon, Brian H., additional, Colletti, Giacomo, additional, Coy, Gustavo, additional, Dallan, Iacopo, additional, Deere, Jackson, additional, Dewart, Nora, additional, Dowling, Eric M., additional, Ebert, Charles S., additional, Eloy, Jean Anderson, additional, Evans, James J., additional, Farber, Nicole I., additional, Farrell, Nyssa Fox, additional, Fastenberg, Judd H., additional, Felisati, Giovanni, additional, Fernandez-Miranda, Juan C., additional, Gardner, Paul A., additional, Gazit, Inbal, additional, Georgalas, Christos, additional, Godfrey, Kyle J., additional, Goldschmidt, Ezequiel, additional, Grayson, Jessica W., additional, Halderman, Ashleigh A., additional, Hardesty, John F., additional, Hartstein, Morris E., additional, Harvey, Richard J., additional, Hernandez, Stephen C., additional, Hink, Eric, additional, Holds, John Bryan, additional, Hsueh, Wayne D., additional, Hwang, Catherine J., additional, Karakasis, Christopher, additional, Kazim, Michael, additional, Kelly, Daniel F., additional, Kelly, Kathleen M., additional, Kimple, Adam J., additional, Kingdom, Todd T., additional, Kraus, Courtney Lynn, additional, Kraus, Howard, additional, Kshettry, Varun R., additional, Kuan, Edward C., additional, Lane, Andrew P., additional, Lanza, Donald Charles, additional, Lee, Victoria S., additional, Lenzi, Riccardo, additional, Liu, James K., additional, Lystad, Lisa D., additional, Maamari, Robi Nicolas, additional, Mangussi-Gomes, João, additional, Metson, Ralph B., additional, Mishra, Kapil, additional, Mitchell, Ron, additional, Moe, Kris S., additional, Muscatello, Luca, additional, Nair, Dileep, additional, Nguyen, John, additional, Novinger, Leah, additional, Nyquist, Gurston G., additional, Or, Lior, additional, Palmer, James N., additional, Perry, Julian D., additional, Piniara, Anastasia, additional, Prevedello, Daniel M., additional, Rabinowitz, Mindy R., additional, Ramadan, Hassan, additional, Recinos, Pablo F., additional, Rivera, Roxana Y., additional, Rosen, Marc R., additional, Roxbury, Christopher R., additional, Ruggieri, Paul, additional, Saadeh, Charles, additional, Sacks, Raymond, additional, Sagar, Soumya, additional, Saibene, Alberto Maria, additional, Santarelli, Griffin D., additional, Schaefer, Jamie Lea, additional, Schwartz, Theodore H., additional, Sen, Rajeev D., additional, Shah, Gopi, additional, Sindwani, Raj, additional, Singh, Arun D., additional, Snyderman, Carl H., additional, Stamm, Aldo C., additional, Stammberger, Heinz, additional, Stokken, Janalee K., additional, Succar, Eric, additional, Svider, Peter F., additional, Tarrats, Luisam, additional, Thorp, Brian D., additional, Ting, Jonathan Y., additional, Tomazic, Peter Valentin, additional, VanKoevering, Kyle K., additional, Vyskocil, Erich, additional, Wang, Eric W., additional, Witterick, Ian J., additional, Wormald, Peter J., additional, Zalzal, Habib, additional, and Zanation, Adam M., additional

Published
2021
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8. Fat embolism syndrome in a child with sickle cell disease

Author

Sohini Chakraborty, Arun Danewa, Sunisha Arora, Saurabh Bansal, Parminder Pal Singh, Rahul Bhargava, and Vikas Dua

Subjects
Fat embolism syndrome, Sickle cell disease, Pediatrics, RJ1-570
Abstract

Background: Fat embolism syndrome (FES) is a rare and underdiagnosed complication associated with sickle cell disease. Case report: We report the case of a 12-year-old girl with sickle cell disease who initially presented with features of acute vaso-occlusive crisis. However, she later developed neurological and respiratory complications along with a decrease in hemoglobin and platelet counts. She was evaluated and diagnosed with FES. The patient was successfully managed with red cell exchange and therapeutic plasma exchange, leading to complete recovery. Conclusion: Prompt diagnosis and early management can significantly improve the outcome of this rare, though highly morbid complication.

Published
2024
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9. Implementing enclosed sterile integrated robotic platforms to improve cell-based screening for drug discovery

Author

Alice Rockliffe, Lauren Wheeler, Kiran Lidhar, Arun Dhar, Michelle Pemberton, Richard Kasprowicz, Ceridwen Hopely, Jo Francis, Shane Marine, David Brierley, and Lorna Suckling

Subjects
Lab automation, Automated biology, Integrated platforms, Cell-based screening, Biotechnology, TP248.13-248.65, Medical technology, R855-855.5
Abstract

At GSK, we have implemented custom integrated robotics platforms housed in bespoke biosafety enclosures to augment our capabilities in advanced cellular screening. Here we present and discuss the impact of one such system, the Cellular Automated Screening Platform (CASPer). We evaluate the benefits of implementing specific processes on CASPer that include increasing the throughput of safety screening assays and improving data integrity when testing complex in vitro 3D primary human hepatocyte models. This article provides an overview of the platforms installed and offers insight into their utilisation by presenting example workflows and quality control solutions which have been implemented. We offer perspective on the advantages of such custom integrated systems and their limitations in cellular screening for early drug discovery.

Published
2025
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10. List of Contributors

Author

Abrams-Tobe, Leslie, primary, Abuswider, Samer A, additional, Acosta, Jorge, additional, Agrawal, Pavi, additional, Albis-Donado, Oscar, additional, Alencar, Luciana M, additional, Allingham, R Rand, additional, Amireskandari, Annahita, additional, Anand, Nitin, additional, Aptel, Florent, additional, Araie, Makoto, additional, Arcieri, Enyr S, additional, Assia, Ehud I, additional, Aung, Tin, additional, Baerveldt, George, additional, Baig, Nafees, additional, Baik, Annie K, additional, Bansal, Rajendra K, additional, Babic, Mirko, additional, Barikian, Anita, additional, Barnebey, Howard, additional, Barton, Keith, additional, Baudouin, Christophe, additional, Beck, Allen, additional, Bennett, Sonya L, additional, Berke, Stanley J, additional, Bevin, Tui H, additional, Bhartiya, Shibal, additional, Bloom, Philip A, additional, Blumberg, Dana M, additional, Bollinger, Kathryn, additional, Bowd, Christopher, additional, Boyle, John W, additional, Brandt, James D, additional, Broadway, David C, additional, Brocchini, Stephen, additional, Bron, Alain M, additional, Budenz, Donald L, additional, Bunce, Catey, additional, Burgoyne, Claude F, additional, Burr, Jennifer, additional, Buys, Yvonne M, additional, Cantor, Louis B, additional, Caprioli, Joseph, additional, Carassa, Roberto G, additional, Casper, Daniel S, additional, Catoira-Boyle, Yara Paula, additional, Ceruti, Piero, additional, Chakrabarti, Debasis, additional, Chakrabarti, Raka, additional, Challa, Pratap, additional, Chan, Errol, additional, Chang, Peter T, additional, Chang, Robert T, additional, Chauhan, Balwantray C, additional, Chen, Aiyin, additional, Cheng, Jason, additional, Chew, Paul TK, additional, Chiang, Mark, additional, Chihara, Etsuo, additional, Choplin, Neil T, additional, Cioffi, George A, additional, Clement, Colin I, additional, Coleman, Anne L, additional, Congdon, Nathan G, additional, Coote, Michael A, additional, Costa, Vital P, additional, Crabb, David P, additional, Crandall, Alan S, additional, Craven, E Randy, additional, Crawley, Laura, additional, Crowston, Jonathan G, additional, Cunningham, Emmett T, additional, Dahan, Elie, additional, Dahlmann-Noor, Annegret H, additional, Damji, Karim F, additional, Day, Alexander, additional, Day, Me'Ja, additional, Denis, Philippe, additional, Dorairaj, Syril, additional, Downs, J Crawford, additional, Dutton, Gordon N, additional, Eldaly, Hassan, additional, El Sayyad, Fathi F, additional, Falsini, Benedetto, additional, Fantes, Francisco, additional, Fechter, Herbert P, additional, Fechtner, Robert D, additional, Fellman, Ronald L, additional, Fenwick, Eva, additional, Fernando, Arosha, additional, Fisher, Ann Caroline, additional, Fitzke, Frederick W, additional, Fortune, Brad, additional, Foster, Paul, additional, Founti, Panayiota, additional, Freedman, Jeffrey, additional, Gandolfi, Stefano A, additional, García-Feijoó, Julián, additional, Garway-Heath, David, additional, Gazzard, Gus, additional, Gedde, Steven J, additional, Geffen, Noa, additional, Georgoulas, Stelios, additional, Giangiacomo, Annette, additional, Gill, Katie, additional, Gkatzioufas, Zisis, additional, Goldberg, Ivan, additional, Gouws, Pieter, additional, Graham, Stuart L, additional, Grajewski, Alana L, additional, Greenfield, David S, additional, Grehn, Franz, additional, Grigera, Daniel E, additional, Gross, Ronald L, additional, Grover, Davinder S, additional, Grytz, Rafael, additional, Gupta, Meenakashi, additional, Gupta, Neeru, additional, de Moraes, Carlos Gustavo, additional, Hafez, Ali S, additional, Hafezi, Farhad, additional, Hamanaka, Teruhiko, additional, Harris, Alon, additional, Hatanaka, Marcelo, additional, Hawker, Matthew J, additional, Healey, Paul R, additional, Heatley, The late Catherine J, additional, Heuer, Dale K, additional, Higginbotham, Eve J, additional, Hirn, Cornelia, additional, Hitchings, Roger A, additional, Holló, Gábor, additional, Hoste, Ann M, additional, Huck, Andrew, additional, Hutnik, Cindy ML, additional, Hylton, Camille, additional, Ittoop, Sabita M, additional, Ja'afar, Farrah, additional, Jampel, Henry, additional, Johnson, Thomas V, additional, Jonas, Jost B, additional, Kahook, Malik Y, additional, Kass, Michael A, additional, Katsanos, Andreas, additional, Katz, L Jay, additional, Keeffe, Jill E, additional, Kersey, Thomas, additional, Khachatryan, Naira, additional, Khaw, Sir Peng Tee, additional, Khouri, Albert S, additional, Kiage, Dan, additional, Kiang, Lee, additional, Kim, Danny, additional, Kiuchi, Yoshiaki, additional, Klink, Thomas, additional, Koenigsman, Helen, additional, Konstas, Anastasios GP, additional, Kotecha, Aachal, additional, Kulkarni, Avinash, additional, Kuroyedov, Alexander V, additional, Labbé, Antoine, additional, Lacey, Alan, additional, Lam, Dennis SC, additional, Lamourex, Ecosse L, additional, Lee, Graham, additional, Lee, Paul, additional, Lemij, Hans G, additional, Leoncavallo, Anthony, additional, Lesk, Mark R, additional, Leung, Christopher KS, additional, Leung, Dexter YL, additional, Levin, Leonard A, additional, Lewis, Richard A, additional, Lim, K Sheng, additional, Lim, Ridia, additional, Lima, Ricardo de, additional, Liu, Yutao, additional, Lockwood, Alastair, additional, Low, Sancy, additional, Mabuchi, Fumihiko, additional, Mackey, David A, additional, Malik, Rizwan, additional, Mandal, Anil K, additional, Mansberger, Steven L, additional, Mansouri, Kaweh, additional, Marchini, Giorgio, additional, Marella, Manjula, additional, Martin, Keith R, additional, McGlynn, Robert H, additional, McKinley, Steven H, additional, McKinnon, Stuart J, additional, McManus, J Ryan, additional, Medeiros, Felipe A, additional, Mermoud, André, additional, Migdal, Clive S, additional, Minckler, Don, additional, Molteno, Anthony CB, additional, Mora, Paolo, additional, Moreno-Montañés, Javier, additional, Morgan, James E, additional, Mosaed, Sameh, additional, Moschos, Marilita M, additional, Muir, Kelly W, additional, Muñoz, Gonzalo, additional, Muñoz-Negrete, Francisco J, additional, Neelakantan, Arvind, additional, Negi, Anil K, additional, Netland, Peter A, additional, Newman-Casey, Paula Anne, additional, Nicolela, Marcelo T, additional, Niyadurupola, Nuwan, additional, Nofal, Magdy A, additional, Nolan, Winnie, additional, Nongpiur, Monisha E, additional, Noureddin, Baha'a N, additional, Novack, Gary D, additional, Nuyen, Brenda, additional, Palaniswamy, Krishnamurthy, additional, Palma, Camille, additional, Park, Ki Ho, additional, Parrish, Richard K, additional, Papadopoulos, Maria, additional, Parikh, Rajul S, additional, Pasquale, Louis R, additional, Pébay, Alice, additional, Petrov, Sergey, additional, Piltz-Seymour, Jody, additional, Pinto, Luís Abegão, additional, Pitha, Ian F, additional, Pfeiffer, Norbert, additional, Quaranta, Luciano, additional, Ramulu, Pradeep Y, additional, Ravinet, Emilie, additional, Realini, Tony, additional, Rebolleda, Gema, additional, Reus, Nic J, additional, Reynolds, Adam C, additional, Rhee, Douglas J, additional, Riss, Isabelle, additional, Ritch, Robert, additional, Riva, Charles E, additional, Roberti, Gloria, additional, Roberts, Cynthia J, additional, Robin, Alan L, additional, Rojanapongpun, Prin, additional, Roy, Sylvain, additional, Salmon, John F, additional, Sampaolesi, Juan Roberto, additional, Sangermani, Chiara, additional, Sarodia, Usman A, additional, Schaefer, Jamie Lea, additional, Schloetzer-Schrehardt, Ursula, additional, Schultz, Gregory S, additional, Schuman, Joel S, additional, Seibold, Leonard K, additional, Shaarawy, Tarek M, additional, Shah, Peter, additional, Sherwood, Mark B, additional, Shiroma, Lineu Oto, additional, Siesky, Brent, additional, Silva, Sergio Estrela, additional, Singh, Annapurna, additional, Singh, Arun D, additional, Singh, Kuldev, additional, Sng, Chelvin CA, additional, Song, Brian J, additional, Spaeth, George L, additional, Spratt, Alexander, additional, Stalmans, Ingeborg, additional, Stamper, Robert L, additional, Sugiyama, Kazuhisa, additional, Susanna, Remo, additional, Suwanpimolkul, Orathai, additional, Swanson, William H, additional, Tamm, Ernst R, additional, Tania Tai, Tak Yee, additional, Tanna, Angelo P, additional, Teekhasaenee, Chaiwat, additional, Tham, Clement CY, additional, Thieme, Hagen, additional, Thomas, Ravi, additional, Thompson, Andrew M, additional, Thulasiraj, Ravilla D, additional, Thygesen, John, additional, Tomey, Karim, additional, Ton, Yokrat, additional, Topouzis, Fotis, additional, Toris, Carol B, additional, Tosi, Roberto, additional, Tsai, James C, additional, Tuli, Sonal S, additional, Tuulonen, Anja, additional, Ungaro, Nicola, additional, Vale, Luke, additional, van Koolwijk, Leonieke ME, additional, Vaswani, Reena S, additional, Venkatesh, Rengaraj, additional, Venturini, Cristina, additional, Vernon, Stephen A, additional, Vithana, Eranga N, additional, Vijaya, Lingam, additional, Viswanathan, Ananth C, additional, Vizzari, Gabriele, additional, Voudouragkaki, Irini C, additional, Waisbourd, Michael, additional, Walland, Mark J, additional, Weinreb, Robert N, additional, Werner, Mark, additional, Wells, Anthony, additional, Wiafe, Boateng, additional, Wilensky, Jacob, additional, Wong, Tina T, additional, WuDunn, Darrell, additional, Yip, Jennifer LY, additional, Yucel, Yeni, additional, Zangwill, Linda M, additional, Zanutigh, Virginia E, additional, Zelefsky, Joseph R, additional, and Zeyen, Thierry, additional

Published
2015
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12. Neovascular Glaucoma

Author

Palma, Camille, primary, Kim, Danny, additional, Singh, Arun D, additional, and Singh, Annapurna, additional

Published
2015
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13. Intraorbital Pathology (Tumors) and Management Strategies

Author

Arun D. Singh, Roxana Y. Rivera, and Anais L. Carniciu

Subjects
Clinical Practice, medicine.medical_specialty, Demographics, business.industry, Medicine, Radiology, Presentation (obstetrics), business
Abstract

Orbital tumors encompass a range of lesions, from congenital cystic masses to benign and malignant neoplasms. This chapter reviews the most important and common intraorbital tumors that are encountered in clinical practice. The associated demographics, clinical presentation, diagnosis, and management of each tumor are discussed.

Published
2021
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14. Contributors

Author

Omar H. Ahmed, Shaheryar F. Ansari, Leopold Arko, Catherine Banks, Garni Barkhoudarian, Federico Biglioli, Benjamin S. Bleier, Kofi Boahene, Hamid Borghei-Ravazi, Zachary J. Cappello, Anais L. Carniciu, Ricardo L. Carrau, Matthew Cassidy, Rakesh Chandra, Chandala Chitguppi, Brian H. Chon, Giacomo Colletti, Gustavo Coy, Iacopo Dallan, Jackson Deere, Nora Dewart, Eric M. Dowling, Charles S. Ebert, Jean Anderson Eloy, James J. Evans, Nicole I. Farber, Nyssa Fox Farrell, Judd H. Fastenberg, Giovanni Felisati, Juan C. Fernandez-Miranda, Paul A. Gardner, Inbal Gazit, Christos Georgalas, Kyle J. Godfrey, Ezequiel Goldschmidt, Jessica W. Grayson, Ashleigh A. Halderman, John F. Hardesty, Morris E. Hartstein, Richard J. Harvey, Stephen C. Hernandez, Eric Hink, John Bryan Holds, Wayne D. Hsueh, Catherine J. Hwang, Christopher Karakasis, Michael Kazim, Daniel F. Kelly, Kathleen M. Kelly, Adam J. Kimple, Todd T. Kingdom, Courtney Lynn Kraus, Howard Kraus, Varun R. Kshettry, Edward C. Kuan, Andrew P. Lane, Donald Charles Lanza, Victoria S. Lee, Riccardo Lenzi, James K. Liu, Lisa D. Lystad, Robi Nicolas Maamari, João Mangussi-Gomes, Ralph B. Metson, Kapil Mishra, Ron Mitchell, Kris S. Moe, Luca Muscatello, Dileep Nair, John Nguyen, Leah Novinger, Gurston G. Nyquist, Lior Or, James N. Palmer, Julian D. Perry, Anastasia Piniara, Daniel M. Prevedello, Mindy R. Rabinowitz, Hassan Ramadan, Pablo F. Recinos, Roxana Y. Rivera, Marc R. Rosen, Christopher R. Roxbury, Paul Ruggieri, Charles Saadeh, Raymond Sacks, Soumya Sagar, Alberto Maria Saibene, Griffin D. Santarelli, Jamie Lea Schaefer, Theodore H. Schwartz, Rajeev D. Sen, Gopi Shah, Raj Sindwani, Arun D. Singh, Carl H. Snyderman, Aldo C. Stamm, Heinz Stammberger, Janalee K. Stokken, Eric Succar, Peter F. Svider, Luisam Tarrats, Brian D. Thorp, Jonathan Y. Ting, Peter Valentin Tomazic, Kyle K. VanKoevering, Erich Vyskocil, Eric W. Wang, Ian J. Witterick, Peter J. Wormald, Habib Zalzal, and Adam M. Zanation

Published
2021
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17. Contributors

Author

Abràmoff, Michael, primary, Abrams, Gary W., additional, Agarwal, Anita, additional, Ai, Everett, additional, Aiello, Lloyd M., additional, Aiello, Lloyd Paul, additional, Albert, Daniel M., additional, Aschbrenner, Mathew W., additional, Ávila, Marcos, additional, Aylward, G. William, additional, Bedell, Matthew, additional, Belfort, Rubens, additional, Bennett, Jean, additional, Bergstrom, Chris, additional, Besirli, Cagri G., additional, Bhende, Pramod S., additional, Binder, Susanne, additional, Bird, Alan C., additional, Blodi, Barbara A., additional, Blumenkranz, Mark S., additional, Boldt, H. Culver, additional, Bornfeld, Norbert, additional, Bottoni, Ferdinando, additional, Boulton, Michael E., additional, Bowne, Sara J., additional, Brantley, Milam A., additional, Bressler, Neil M., additional, Bressler, Susan B., additional, Bringmann, Andreas, additional, Brinton, Daniel A., additional, Brown, Gary C., additional, Brown, Justin C., additional, Brunner, Simon, additional, Bush, Ronald A., additional, Cao, Dingcai, additional, Capone, Antonio, additional, Carruthers, David, additional, Cavallerano, Jerry D., additional, Chakravarthy, Usha, additional, Chan, Chi-Chao, additional, Chan, Waiman, additional, Charles, Steven, additional, Charteris, David G., additional, Chen, Dong Feng, additional, Chen, Jeannie, additional, Chen, Youxin, additional, Cheung, Carol Yim Lui, additional, Chew, Emily Y., additional, Chiang, Allen, additional, Chiang, Michael F., additional, Constable, Ian J., additional, Coscas, Gabriel, additional, Cruess, Alan F., additional, Cunningham, Emmett T., additional, Curcio, Christine A., additional, Daiger, Stephen P., additional, Damato, Bertil E., additional, Davis, Janet L., additional, Davis, Matthew D., additional, Day, Shelley, additional, De Potter, Patrick, additional, de Smet, Marc D., additional, Denniston, Alastair K., additional, Dhaliwal, Ranjit S., additional, Ding, Xiaoyan, additional, Do, Diana V., additional, Dou, Guorui, additional, Dunn, William A., additional, Ehlers, Justis P., additional, Engelbert, Michael, additional, Faia, Lisa J., additional, Falsini, Benedetto, additional, Fawzi, Amani A., additional, Fekrat, Sharon, additional, Feldon, Steven E., additional, Fernandes, Rodrigo A. Brant, additional, Ferreyra, Henry A., additional, Ferrington, Deborah A., additional, Ferris, Frederick L., additional, Finger, Paul T., additional, Fisher, Steven K., additional, Fishman, Gerald A., additional, Fleckenstein, Monika, additional, Flynn, Harry W., additional, Fok, Andrew C., additional, Foulds, Wallace S., additional, Freeman, William R., additional, Freton, Aurélien, additional, Friedlander, Martin, additional, Frishman, Laura J., additional, Fu, Arthur D., additional, Garcia Filho, Carlos Alexandre de Amorim, additional, Garcia-Valenzuela, Enrique, additional, Gaudric, Alain, additional, Gayed, Mary, additional, Genead, Mohamed A., additional, Gerding, Heinrich, additional, Giani, Andrea, additional, Goldberg, Morton F., additional, Gombos, Dan S., additional, Gopal, Lingam, additional, Gordon, Caroline, additional, Goto, Hiroshi, additional, Gragoudas, Evangelos S., additional, Grant, Maria B., additional, Green, W. Richard, additional, Gregg, Ronald G., additional, Gregor, Zdenek, additional, Gregori, Giovanni, additional, Gregory-Evans, Kevin, additional, Grob, Seanna, additional, Groenewald, Carl, additional, Grossniklaus, Hans E., additional, Grover, Sandeep, additional, Gullapalli, Vamsi K., additional, Gupta, Aditi, additional, Guthoff, Rudolf F., additional, Hahn, Paul, additional, Haller, Julia A., additional, Harbour, J. William, additional, Haritoglou, Christos, additional, Hartnett, Mary E., additional, Hawkins, Barbara S., additional, He, Shikun, additional, Herwig, Martina C., additional, Heussen, Florian M.A., additional, Hinton, David R., additional, Holz, Frank G., additional, Houston, Samuel K., additional, Hui, Yan-Nian, additional, Humayun, Mark S., additional, Ikuno, Yasushi, additional, Isaac, David, additional, Ishibashi, Tatsuro, additional, Jabs, Douglas A., additional, Jaffe, Glenn J., additional, Jampol, Lee M., additional, Joffe, Leonard, additional, Johnson, Mark, additional, Johnson, Mark W., additional, Johnson, Robert N., additional, Joussen, Antonia M., additional, Julian, Karina, additional, Jumper, J. Michael, additional, Kaiser, Peter K., additional, Kampik, Anselm, additional, Katamay, Robert, additional, Kay, Christine N., additional, Keane, Pearse A., additional, Kenney, M. Cristina, additional, Khaderi, Khizer R., additional, Khodair, Mohamad A., additional, Kim, Ivana K., additional, Kim, Tae Wan, additional, Kirchhof, Bernd, additional, Klein, Barbara E.K., additional, Klein, Ronald, additional, Konstantinidis, Lazaros, additional, Kozak, Igor, additional, Kuppermann, Baruch D., additional, Labriola, Leanne T., additional, Lai, Timothy Y., additional, Lam, Dennis S., additional, Lam, Linda A., additional, Landers, Maurice B., additional, Lane, Anne Marie, additional, Lavik, Erin B., additional, Leary, James F., additional, Lee, Sun Young, additional, Lee, Thomas C., additional, Leung, Loh-Shan B., additional, Lewis, David A., additional, Lewis, Geoffrey P., additional, Leys, Anita, additional, Li, Xiaoxin, additional, Liakopoulos, Sandra, additional, Lin, Chang-Ping, additional, Lin, Phoebe, additional, Liu, David T., additional, London, Nikolas J.S., additional, Lujan, Brandon J., additional, Luo, Yan, additional, Lutty, Gerard A., additional, MacLaren, Robert, additional, Madreperla, Steven, additional, Maguire, Albert M., additional, Mainster, Martin A., additional, Mansfield, Nancy C., additional, Markoe, Arnold M., additional, Marmor, Michael F., additional, Martin, Daniel F., additional, Massey, Stephen C., additional, McCall, Maureen A., additional, McCannel, Tara A., additional, McCutchan, J. Allen, additional, McDonald, H. Richard, additional, Mehta, Milap P., additional, Meier, Petra, additional, Merbs, Shannath, additional, Meredith, Travis A., additional, Meyer, Carsten H., additional, Mieler, William F., additional, Miller, Joan W., additional, Mirza, Rukhsana G., additional, Mitter, Sayak K., additional, Mittra, Robert A., additional, Miyake, Yozo, additional, Montemagno, Carlo, additional, Moshiri, Ala, additional, Mruthyunjaya, Prithvi, additional, Muccioli, Cristina, additional, Mullins, Robert F., additional, Murata, Toshinori, additional, Murphree, A. Linn, additional, Murphy, Robert P., additional, Murray, Philip I., additional, Murray, Timothy G., additional, Nagpal, Manish, additional, Namperumalsamy, Perumalsamy, additional, Nanda, Sumit K., additional, Nguyen, Quan Dong, additional, Nussenblatt, Robert B., additional, Oh, Kean T., additional, Ohji, Masahito, additional, Ohno-Matsui, Kyoko, additional, Palanker, Daniel, additional, Patel, Purnima S., additional, Pavlick, Anna C., additional, Peereboom, David M., additional, Pennesi, Mark E., additional, Pepose, Jay S., additional, Perry, Julian D., additional, Puliafito, Carmen A., additional, Quiram, Polly A., additional, Raman, Rajiv, additional, Ramchandran, Rajeev S., additional, Rao, Haripriya Vittal, additional, Rao, Narsing A., additional, Rao, P. Kumar, additional, Rathinam, Sivakumar R., additional, Recchia, Franco M., additional, Redmond, Kristin J., additional, Reh, Thomas A., additional, Reichenbach, Andreas, additional, Ritch, Robert, additional, Rosenfeld, Philip J., additional, Rubin, Gary S., additional, Ruiz-Garcia, Humberto, additional, Ryan, Stephen J., additional, Sadda, SriniVas R., additional, Sadun, Alfredo A., additional, Sakamoto, Taiji, additional, Sampath, Alapakkam P., additional, Schachat, Andrew P., additional, Schmitz-Valckenberg, Steffen, additional, Schwartz, Stephen G., additional, Scott, Adrienne W., additional, Sebag, Jerry, additional, Seddon, Johanna M., additional, Sen, H. Nida, additional, Sepah, Yasir Jamal, additional, Sharma, Sanjay, additional, Sharma, Tarun, additional, Sheu, Shwu-Jiuan, additional, Shields, Carol L., additional, Shields, Jerry A., additional, Shinoda, Kei, additional, Shukla, Dhananjay, additional, Sieving, Paul A., additional, Silva, Paolo A.S., additional, Silveira, Claudio, additional, Singh, Arun D., additional, Smith, Sylvia B., additional, Smith, Wendy M., additional, Sobrin, Lucia, additional, Sodhi, Akrit, additional, Sohn, Elliott H., additional, Soubrane, Gisèle, additional, Spielberg, Leigh, additional, Srivastava, Sunil K., additional, Stachs, Oliver, additional, Staurenghi, Giovanni, additional, Sternberg, Paul, additional, Stone, Edwin M., additional, Sugino, Ilene K., additional, Sullivan, Lori S., additional, Sullivan, Paul, additional, Sun, Jennifer K., additional, Sunness, Janet S., additional, Tadayoni, Ramin, additional, Tang, Shibo, additional, Terasaki, Hiroko, additional, Thomas, Matthew A., additional, Thompson, John T., additional, Thumann, Gabriele, additional, Toth, Cynthia A., additional, Trese, Michael T., additional, Tsai, Julie H., additional, Turell, Mary E., additional, Turner, Patricia L., additional, Udar, Nitin, additional, Ulrich, J. Niklas, additional, Van Gelder, Russell N., additional, van Meurs, Jan C., additional, Vasconcelos-Santos, Daniel Vítor, additional, Vavvas, Demetrios G., additional, Vemulakonda, G. Atma, additional, Wang, Hao, additional, Wang, Yusheng, additional, Weiland, James D., additional, Weleber, Richard G., additional, Wharam, Moody D., additional, Wickham, Louisa, additional, Wiedemann, Peter, additional, Wiley, Henry E., additional, Wilkinson, C.P., additional, Wilson, David J., additional, Wolfensberger, Thomas J., additional, Wong, David, additional, Wong, Ian Y., additional, Wong, Tien Yin, additional, Wu, David M., additional, Yandiev, Yanors, additional, Yang, Chang-Hao, additional, Yang, Chung-May, additional, Yannuzzi, Lawrence A., additional, Yasuda, Miho, additional, Yeh, Po-Ting, additional, Yehoshua, Zohar, additional, Yiu, Glenn, additional, Yoon, Young Hee, additional, Yu, Hyeong Gon, additional, Yuan, Alex, additional, Zarbin, Marco A., additional, Zhang, Jun Jun, additional, Zhang, Kang, additional, Zhao, Mingwei, additional, and Zhou, Peng, additional

Published
2013
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20. Preface

Author

Singh, Arun D., primary and Hayden, Brandy C., additional

Published
2012
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21. List of contributors

Author

Ahmed, Iqbal Ike K., primary, Altan-Yaycioglu, Rana, additional, Aylward, George William, additional, Azuara-Blanco, Augusto, additional, Bagnis, Alessandro, additional, Baldeschi, Lelio, additional, Banitt, Michael R., additional, Barton, Keith, additional, Baskin, Darrell E., additional, Baumeister, Martin, additional, Bellucci, Roberto, additional, Benjamin, Larry, additional, Berdahl, John P., additional, Brazier, John, additional, Brod, Roy D., additional, Bühren, Jens, additional, Freidl, Kathryn Burleigh, additional, Busin, Massimo, additional, Cantor, Louis B., additional, Carassa, Roberto G., additional, Colin, Joseph, additional, Coupland, Sarah E., additional, Damato, Bertil, additional, Dresner, Steven C., additional, Dupps, William J., additional, Eke, Tom, additional, Elder, Mark J., additional, Elies, Daniel, additional, Elizalde, Javier, additional, Epstein, Daniel, additional, Fine, I. Howard, additional, Fineman, Mitchell S., additional, Flynn, Harry W., additional, Freedman, Jeffrey, additional, Gandorfer, Arnd, additional, Gardner, Thomas W., additional, Goldberg, Robert A., additional, Goyal, Saurabh, additional, Gris, Oscar, additional, Groenewald, Carl, additional, Güell, Jose L., additional, Gupta, Shelly R., additional, Hallahan, Katie, additional, Han, Dennis P., additional, Haritoglou, Christos, additional, Heimann, Heinrich, additional, Hetzler, Kathy J., additional, Hintschich, Christoph, additional, Hoffman, Richard S., additional, Holz, Frank G., additional, Hutchinson, Amy K., additional, Hwang, Catherine J., additional, Iyengar, Srinivas S., additional, Johnston, Robert L., additional, de Juan, Eugene, additional, Uzbek, Aylin Kılıç, additional, Dipl-Ing, Oliver K. Klaproth, additional, Kohnen, Thomas, additional, Kontadakis, Georgios A., additional, Kook, Daniel, additional, Kymionis, George D., additional, Lambert, Scott R., additional, Lawrence, Scott D., additional, Lee, Richard K., additional, Li, Tina G., additional, Lin, Phoebe, additional, Lindsay, Rebecca Anderson, additional, Little, Brian C., additional, Macrì, Angelo, additional, Malen, Marissa R., additional, Manero, Felicidad, additional, Marinho, Antonio, additional, McCannel, Tara A., additional, Miller, Darlene, additional, Moorman, Consuela, additional, Morral, Merce, additional, Moster, Marlene R., additional, Netland, Peter A., additional, Ng, John D., additional, Nischal, Ken K., additional, Nunery, William R., additional, O’Brien, Joan, additional, Olver, Jane, additional, Packer, Mark, additional, Papadia, Marina, additional, Pasquale, Louis R., additional, Patel, Amit, additional, Patel, Shuchi B., additional, Pe’er, Jacob, additional, Poetter, Richard, additional, Prasad, Som, additional, Quillen, David A., additional, Ritch, Robert, additional, Rose, Geoffrey E., additional, Bsc, Paul Rosen, additional, Samuelson, Thomas W., additional, Schachat, Andrew P., additional, Schalenbourg, Ann, additional, Schaudig, Ulrich H., additional, Schorr, Norman, additional, Scotto, Riccardo, additional, Sculfor, David, additional, Shields, Carol L., additional, Shields, Jerry A., additional, Shun-Shin, Georges Adrien, additional, Siganos, Dimitrios S., additional, Singh, Arun D., additional, Skalet, Alison H., additional, Smith, Jennifer Hasenyager, additional, Sokol, Jason A., additional, Spaeth, George L., additional, Stanzel, Boris V., additional, Sullivan, Timothy J., additional, Tadayoni, Ramin, additional, Tam, Diamond Y., additional, Tham, Clement C.Y., additional, Timoney, Peter J., additional, Traverso, Carlo Enrico, additional, Tyers, Anthony G., additional, Uzcategui, Nicolas, additional, Venzano, Davide, additional, Verity, David H., additional, Watts, Mark T., additional, Wickham, Louisa, additional, Yee, Allison B., additional, Zehetmayer, Martin, additional, and Zografos, Leonidas, additional

Published
2012
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24. Glaucoma

Author

Rockwood, Edward J., primary, Hayden, Brandy C., additional, and Singh, Arun D., additional

Published
2012
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28. List of Contributors

Author

Allemann, Norma, primary, Archer, Timothy J., additional, Armstrong, Brian K., additional, Broaddus, Erin, additional, Dadgostar, Hajir, additional, Dogra, Vikram S., additional, Dupps, William J., additional, Gayer, Steven, additional, Ginat, Daniel T., additional, Gobbe, Marine, additional, Hayden, Brandy C., additional, Kelley, Linda, additional, Krueger, Ronald R., additional, da Rocha Lima, Breno, additional, Lowder, Careen Y., additional, Lystad, Lisa D., additional, Mello, Glauco Reggiani, additional, Ramos, Maria Helena Mandello Carvalhaes, additional, Reinstein, Dan Z., additional, Rockwood, Edward J., additional, Sachdeva, Reecha, additional, Santhiago, Marcony R., additional, Schoenfield, Lynn, additional, Sears, Jonathan E., additional, Sharma, Sumit, additional, Shaw, Eric Scot, additional, Silverman, Ronald H., additional, Singh, Arun D., additional, Singh, Rishi P., additional, Steinle, Nathan C., additional, Torres, Virgínia L L, additional, Traboulsi, Elias I., additional, Turell, Mary E., additional, and Vasanji, Amit, additional

Published
2012
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29. Intraocular Tumors

Author

Turell, Mary E., primary, Hayden, Brandy C., additional, Schoenfield, Lynn, additional, and Singh, Arun D., additional

Published
2012
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30. Corneal Diseases

Author

Santhiago, Marcony R., primary, Dupps, William J., additional, and Singh, Arun D., additional

Published
2012
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31. Silicon and nitric oxide modulate growth attributes, antioxidant defense system and osmolytes accumulation in radish (Raphanus sativus L.) under arsenic toxicity

Author

Savita Bhardwaj, Tunisha Verma, Jaspreet Kour, Arun Dev Singh, Renu Bhardwaj, Neeta Raj Sharma, Shabnam Ansari, Ali Raza, P.V. Vara Prasad, Usha Thakur, and Dhriti Kapoor

Subjects
Arsenic, Membrane damage, Growth, Metal toxicity, ROS scavenging, Stress physiology, Plant ecology, QK900-989
Abstract

Plants adjust their developmental processes for their survival against changing environments. Plant development is adversely affected by arsenic (As) contamination. In order to mitigate As toxicity, the effect of silicon (Si) (as silicic acid) and nitric oxide (NO) (as sodium nitroprusside; SNP) was observed on 7 days old radish (Raphanus sativus L.) seedlings under 0.3, 0.5 and 0.7 mM As concentrations. Plant growth traits, oxidative stress, carbohydrates, protein, antioxidants and osmolytes were measured. Arsenic stress inhibited the growth parameters and caused oxidative damage by elevating the level of oxidative stress markers and by causing membrane and nuclear damage, as shown by histochemical studies. Activities of antioxidative enzymes, content of non-enzymatic antioxidants, and levels of osmolytes were also decreased by As stress. However, Si and NO supplementation enhanced the As tolerance by improving the plant growth parameters. Moreover, Si and NO application improved carbohydrates and protein contents and stimulated plant antioxidant defense systems by decreasing the level of malondialdehyde and hydrogen peroxide and by diminishing the membrane and nuclear damage caused by As. An increase in the osmolytes levels were observed by the application of Si and NO. Fourier transform infrared analysis showed that Si and NO exerted various peaks in different lipids, proteins, carbohydrates and cell wall component regions. This study suggests that Si and NO can help mitigating As-induced toxicity in R. sativus seedlings and augment growth.

Published
2024
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40. Prefacio

Author

Singh, Arun D., primary, Damato, Bertil E., additional, Pe’er, Jacob, additional, Linn Murphree, A., additional, and Perry, Julian D., additional

Published
2009
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