1. Interleukin-10 - 1082 GG polymorphism influences the occurrence and the clinical characteristics of hepatitis C virus infection.
- Author
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Persico M, Capasso M, Persico E, Masarone M, Renzo Ad, Spano D, Bruno S, and Iolascon A
- Subjects
- Adult, Aged, Alleles, Female, Gene Frequency, Genetic Predisposition to Disease, Genotype, Humans, Interleukin-10 biosynthesis, Lymphoma, B-Cell epidemiology, Lymphoma, B-Cell etiology, Lymphoma, B-Cell genetics, Male, Middle Aged, Polymerase Chain Reaction, Prognosis, RNA, Viral analysis, Retrospective Studies, Risk Factors, DNA genetics, Hepatitis C, Chronic complications, Hepatitis C, Chronic epidemiology, Hepatitis C, Chronic genetics, Interleukin-10 genetics, Polymorphism, Genetic
- Abstract
Background/aims: In this study, we determined the genotypic and allelic frequencies of the Interleukin (IL)-10(-1082G/A) IL-10(-592A/C), and IL-10(-819C/T) polymorphisms, and their association with the risk to develop B cell Non Hodgkin Lymphoma (NHL) in hepatitis virus C (HCV) carriers., Results: Genetic polymorphisms in the IL-10 gene promoter were studied in 250 consecutive patients with B-cell NHL with no clinical and/or laboratory findings of cryoglobulinemia, 142 NHL/HCV- and 108 NHL/HCV+ with chronic hepatitis (CH), 120 consecutive subjects with HCV-related CH, and 110 age, sex-matched healthy blood donors. The frequency of the IL-10(-1082GG) genotype vs remaining genotypes (IL-10(-1082GA/AA)) was higher in NHL/HCV+ patients than HCV-related CH patients (P=0.0002, OR=2.89, CI: 1.62-5.15) and in NHL/HCV+ than NHL/HCV- patients (P=0.0001, OR=2.99, CI: 1.72-5.19). Moreover, the IL-10(-1082GG) genotype was more prevalent in indolent NHL/HCV+ cases than aggressive NHL/HCV+ (P=0.0004, OR=4.97, CI: 2.10-11.79). Finally, we confirmed that IL-10(-1082GG) genotype is associated with higher IL-10 production compared to AA homozygous (P=0.037)., Conclusions: The high IL-10 production, due to IL-10(-1082GG) genotype, influences the clinical expression of the HCV infection by increasing susceptibility to develop NHL and might contribute to the indolent form of the disease.
- Published
- 2006
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