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Daphnauranins A ( 1 ) and B ( 2 ), two sesquiterpenoids were isolated from the roots of Daphne aurantiaca Diels. One is an unprecedented 5/7 oxacycloheptane ring system, the other is a sesquiterpene-lignan complex. Their structures were elucidated by comprehensive spectroscopic methods including MS and NMR. Their absolute configurations were further confirmed by the quantum ECD calculations. Daphnauranins A and B showed anti-insect activities against male fruit fly with anti-feeding rate up to 46.2 ± 7.1 and 44.7 ± 5.4% at 1 mM, respectively. [ABSTRACT FROM AUTHOR]

Five new meroterpenoids, chrodrimanins O–S ( 1 – 5 ), as well as a known one ( 6 ), were isolated from the fermentation broth of Penicillium sp. SCS-KFD09 isolated from a marine worm, Sipunculusnudus , from Haikou Bay, China. The structures including the absolute configurations of the new compounds were unambiguously elucidated by spectroscopic data and ECD spectra analysis along with quantum ECD calculations. Among them, compound 1 represents the first example of an unusual trichlorinated meroterpenoid with an unique dichlorine functionality. Compounds 1 and 4 – 6 displayed inhibitory activity of protein tyrosine phosphatase 1B (PTP1B) with IC 50 values of 71.6, 62.5, 63.1, and 39.6 μM, respectively, and showed no apparent activity against three tumor cell lines (A549, HepG2, and Hela) and human umbilical vein endothelial cells (HUVEC) at 10 μM. [ABSTRACT FROM AUTHOR]

Abstract: Three tigliane-type diterpenoids named excoecafolins A–C and two daphnane-type diterpenoids named excoecafolins D and E, together with 13 known compounds, were isolated from the EtOAc extract of Excoecaria acerifolia Didr. Their structures were elucidated through the analysis of the spectroscopic data. The anti-HIV-1 activity evaluation of five of these compounds showed that four possessed moderate anti-HIV-1 activities with EC50 0.258, 0.036, 0.046, and 0.978 ?M, SI >1,836.9, 431.1, 298.7, and >503.7, respectively. Additionally, the chemotaxonomic issue of the affinity correlation between Thymelaeceae and Euphorbiaceae is discussed based on the isolates. [Copyright &y& Elsevier]

Abstract: Six new steroidal saponins, cambodianosides A–F (1–6), together with seven known ones, were isolated from the dragon's blood of Dracaena cambodiana. The structures of 1–6 were elucidated on the basis of detailed spectroscopic analysis, including 1D and 2D NMR techniques and chemical methods. The cytotoxicities of all the isolated compounds were evaluated in vitro against three human cancer cell lines, and compounds 7, 8, and 11 showed significant inhibitory activities. [Copyright &y& Elsevier]

Abstract: Five new diterpenoids named excocarinols A–E (1–5) including three pimaranes, one cleistanthane, and one nor-beyerane, together with nine known compounds, were isolated from the EtOAc extract of the Chinese ethnodrug Gua-jing-ban (Excoecaria acerifolia Didr.). Their structures were elucidated by the analysis of spectroscopic data including 1D, 2D NMR and HR-MS. The anti-HIV-1 bioassay on the diterpenoids showed that excocarinol A (1) exhibited moderate anti-HIV-1 activity with EC50 5.58?M and SI (Selection Index) over 112.71. [Copyright &y& Elsevier]

Two new norlignan derivatives, crassifoside I ( 1 ) and sinensigenin C ( 2 ), were isolated from the rhizomes of Curculigo capitulate, along with six known norlignan derivatives, 1,1-bis(3,4-dihydroxyphenyl)-1-(2-furan)-methane ( 3 ), crassifogenin B ( 4 ), crassifoside A ( 5 ), breviscaside A ( 6 ), crassifoside D ( 7 ), and curcapital ( 8 ). Their structures were elucidated on the basis of spectral evidence and comparisons with literature data. The 1H and 13C NMR data of compound 3 was first assigned. Compounds 3 – 7 were isolated from this plant for the first time. [Copyright &y& Elsevier]