1. Cyclodextrins as excipients in tablet formulations.
- Author
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Conceição, Jaime, Adeoye, Oluwatomide, Cabral-Marques, Helena Maria, and Lobo, José Manuel Sousa
- Subjects
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CYCLODEXTRINS , *EXCIPIENTS , *DRUG tablets , *DRUG development , *DRUG dosage - Abstract
This paper aims to provide a critical review of cyclodextrins as excipients in tablet formulations, highlighting: (i) the principal pharmaceutical applications of cyclodextrins; (ii) the most relevant technological aspects in pharmaceutical formulation development; and (iii) the actual regulatory status of cyclodextrins. Moreover, several illustrative examples are presented. Cyclodextrins can be used as complexing excipients in tablet formulations for low-dose drugs. By contrast, for medium-dose drugs and/or when the complexation efficiency is low, the methods to enhance the complexation efficiency play a key part in reducing the cyclodextrin quantity. In addition, these compounds are used as fillers, disintegrants, binders and multifunctional direct compression excipients of the tablets. [ABSTRACT FROM AUTHOR]
- Published
- 2018
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