51. A Glance on target specific PDT active cyclometalated iridium complexes.
- Author
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Das, Rishav, Das, Ushasi, Roy, Nilmadhab, Mukherjee, Chandrapaul, U, Sreelekha, and Paira, Priyankar
- Subjects
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IRIDIUM , *REACTIVE oxygen species , *PHOTODYNAMIC therapy , *CELL imaging , *CYTOTOXINS , *RESEARCH personnel , *LIGANDS (Chemistry) - Abstract
Light is indispensable to every aspect of our life. It is also a very important component of photodynamic therapy to cure cancer. Photodynamic therapy is a modern and effective technique among all these prevailing anticancer therapies because of its uniqueness in selectivity. Organometallic complexes are seen to be better candidates for photodynamic therapy. Cyclometalated complexes have been developed for targeting cellular organelles with remarkable photoactivity. Different types of metal complexes can display PDT activity. Considering its photophysical characteristics, the iridium complex is the most effective alternative to use as a PDT agent. Iridium-based cyclometalated complexes have shown decent results as a PDT-active anti-cancer agent. Reactive oxygen species (ROS) and singlet oxygen with high singlet oxygen quantum yield are both extremely capable of being produced by complexes. High cytotoxicity has been exhibited by various Iridium-based cyclometalated complexes in the presence of light and negligible cytotoxicity in dark conditions. These complexes are considerably fluorescent with the capability of cellular imaging and have displayed very significant potency against HeLa, A549, MCF-7, and other various cell lines. Complexes can arrest the different paths of the cell cycle through different mechanisms and help to force cellular apoptosis. Hence, a galore of organelle-targeted cyclometalated iridium complexes has been showcased in this review article. • Summarizing Current Research: This review papers provide an overview of existing literature on a particular topic. It summarizes the current research and advancements in the field of photodynamic therapy using cyclometalated iridium complexes. • Identifying Trends and Gaps: By analyzing various studies, the review can identify trends in research, such as the most effective types of complexes or promising targeting strategies. It highlights gaps in knowledge or areas where further research is needed. • Consolidating Information: Research in the field of photodynamic therapy using cyclometalated iridium complexes may be scattered across various journals and publications. This review paper consolidates this information into one place, making it easier for researchers and clinicians to access and understand. • Informing Future Research Directions: This review paper can suggest future research directions or areas that warrant further investigation. This can help guide researchers in their studies and experiments. • Educational Resource: This review paper serves as a valuable educational resource for students, researchers, and practitioners. It provides an in-depth understanding of this specific topic and can be used as a reference in academic settings. • Impact on Clinical Practice: Ultimately, the goal of research in this area is to develop more effective treatments for various diseases, such as cancer. This review paper highlights the promising cyclometalated iridium complexes for photodynamic therapy that could have a direct impact on clinical practice by informing the development of new therapeutic strategies. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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