1. Cu(I)-catalyzed synthesis of N-tosyl-4-iminoquinolizines.
- Author
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Chen, Joanna L., Namirembe, Sheila, Lauchert, Luke T., Tsougranis, Gregory H., and Isaacs, André K.
- Subjects
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COPPER catalysts , *QUINOLIZINES , *HETEROCYCLIC compounds synthesis , *PYRIDINE , *NUCLEOPHILES , *RING formation (Chemistry) , *INTERMOLECULAR interactions - Abstract
Pyridines were found to be a convenient nucleophile in the copper(I)-catalyzed synthesis of N -tosyl-4-iminoquinolizines from 2-pyridyl compounds. Intramolecular cyclization of an in situ generated ketenimine and a tethered pyridine, followed by a base-promoted oxidation, affords the desired products in moderate to good yields under mild reaction conditions. [ABSTRACT FROM AUTHOR]
- Published
- 2015
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