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1. Role of UHRF1 in malignancy and its function as a therapeutic target for molecular docking towards the SRA domain.

Author

Polepalli, Sravani, George, Sophia M, Valli Sri Vidya, R, Rodrigues, Gabriel Sunil, Ramachandra, L., Chandrashekar, Raghu, M, Deepak Nayak, Rao, Praveen P.N., Pestell, Richard G., and Rao, Mahadev

Subjects
*MOLECULAR docking, *PROTEIN synthesis, *TUMOR grading, *TUMOR proteins, *EMODIN
Abstract

• UHRF1 is upregulated in several cancers. • UHRF1 levels are associated with stage, size and grade of the tumor. • UHRF1 can be used as a druggable target. • Docking of Propranolol, Nocodazole, Thymoquinone, Emodin, Napthazarin to SRA domain. The figure describes the location of UHRF1 (Ubiquitin-like with containing PHD and RING Finger domains 1) gene, mRNA and protein synthesis in the tumor cell and its structural domains with a focus on the docking of Naphthazarin on the SRA domain of UHRF1, resulting in reduction of tumor size. [ABSTRACT FROM AUTHOR]

Published
2019
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