1. Type 1 interferons as a potential treatment against COVID-19.
- Author
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Sallard, Erwan, Lescure, François-Xavier, Yazdanpanah, Yazdan, Mentre, France, and Peiffer-Smadja, Nathan
- Subjects
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COVID-19 , *TYPE I interferons , *INTERFERONS , *SARS-CoV-2 , *SARS virus , *INTERFERON beta-1a , *MERS coronavirus , *CORONAVIRUSES - Abstract
Type 1 interferons have a broad antiviral activity in vitro and are currently evaluated in a clinical trial to treat MERS-CoV. In this review, we discuss preliminary data concerning the potential activity of type 1 interferons on SARS-CoV-2, and the relevance of evaluating these molecules in clinical trials for the treatment of COVID-19. • Interferon treatment has shown mixed efficiency against SARS-CoV and MERS-CoV. • SARS-CoV-2 is probably more sensitive to interferon than the other coronaviruses. • The IFNβ subtype appears to be the most suited for COVID-19 treatment. • Interferon treatment should be performed in the early stages of the infection. • Investigation on interferon-based COVID-19 treatment is warranted. [ABSTRACT FROM AUTHOR]
- Published
- 2020
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