1. ALLERGIC CONTACT SENSITIZATION TO THE TOLUIC ACIDS.
- Author
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Emmett, Edward A. and Suskind, Raymond R.
- Subjects
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ALLERGIES , *PROTEINS , *HAPTENS , *ANTIGENS , *BIOMOLECULES , *ORGANIC compounds - Abstract
Para-toluic acid (1:4 methylbenzoic acid) and ortho-toluic acid were found to be potent allergic sensitizers when applied to human skin. Cross-sensitivity was found between all three isomers, p-toluic, m-toluic, and o-toluic acids. It is suggested that this cross-sensitivity is explicable in terms of carrier protein specificity rather than by the presence of a common chemical sequence in the hapten or by conversion of the cross-reactants to an identical hapten. [ABSTRACT FROM AUTHOR]
- Published
- 1973
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