Search

Your search keyword '"Szili, Noémi"' showing total 1 results
Start Over Author "Szili, Noémi" Publisher elsevier b.v.
1 results on '"Szili, Noémi"'

1. Insights into Streptococcus agalactiae PI-2b pilus biosynthesis and role in adherence to host cells.

Author

Périchon, Bruno, Guignot, Julie, Szili, Noémi, Gao, Cherry, Poyart, Claire, Trieu-Cuot, Patrick, and Dramsi, Shaynoor

Subjects
*STREPTOCOCCUS agalactiae, *CELL adhesion, *BIOSYNTHESIS, *PHAGOCYTOSIS, *ENDOTHELIAL cells
Abstract

Abstract The core PI-2b pilus present in "hypervirulent" ST-17 Streptococcus agalactiae strains consists of three pilin subunits (Spb1, Ap1 and Ap2) assembled by sortase SrtC1 and cell-wall anchored by Srt2. Spb1 was shown to be the major pilin and Ap2 the anchor pilin. Ap1 is a putative adhesin. Two additional genes, orf and lep , are part of this operon. The contribution of Lep and Ap1 to the biogenesis of the PI-2b pilus was investigated. Concerning the role of PI-2b, we found that higher PI-2b expression resulted in higher adherence to human brain endothelial cells and higher phagocytosis by human THP1 macrophages. [ABSTRACT FROM AUTHOR]

Published
2019
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results