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• A homogenous polysaccharide SPS60 was isolated from Sabia parviflora. • The monosaccharide component of SPS60 was glucose. • SPS60 showed significant hepatoprotective activity. • The AFM images showed SPS60 was a massive sphere with a diameter of 21 nm. The extraction, purification, structure and hepatoprotective activity of a homogenous polysaccharide (SPS60) from Sabia parviflora were investigated. SPS60 was screened after purification with Sephadex G-100 and showed the excellent hepatoprotective activity. Its structural characteristics were investigated by Time of flight mass spectrometry (TOF-MS), PMP Pre-column derivatization-HPLC (PMP-HPLC), nuclear magnetic resonance (NMR) spectroscopy and Atomic Force Microscopy (AFM). The results showed that SPS60 possessed the molecular weight of 16900 Da and the monosaccharide component was glucose, as well as a 1 → 6 glycosidic bond. The results of atomic force microscopy (AFM) show that SPS60 is a blocky sphere in solution. Furthermore, the SPS60 could significantly improve the survival rate of LO2 hepatocytes which were damaged by CCl 4. Therefore, SPS60 may be an active substance of S. parviflora as a local functional tea. [ABSTRACT FROM AUTHOR]

• Stable multi domain wall states containing two or more domain walls can be obtained based on our microscopic model. • A novel hybrid st ate consisting of two domain walls and one centered vortex tends to emerge as the zero field ground state of the rectangular system. • Complex coreless skyrmionic states with different enclosed structures of domain walls c an appear in the rectangular sample. In the framework of the microscopic Bogoliubov-de Gennes theory, we investigate the topological defect states in mesoscopic chiral p -wave superconducting rectangles. In the absence of applied magnetic field, stable multi-domain-wall states containing two or more domain walls can be obtained with the increase of the aspect ratio of the rectangle at zero temperature. When the external field is applied, the multi-domain-wall state can only be found as the ground state at finite flux. Interestingly, a hybrid state consisting of two domain walls and one centered vortex tends to emerge as the zero-field ground state of the rectangular system. For enlarged applied flux, several coreless skyrmionic states with different enclosed structures of domain walls as well as the half-quantum vortex-antivortex pair can appear in the present sample. [ABSTRACT FROM AUTHOR]

Five new guaiane-type sesquiterpene lactones, caroguaianolide A–E ( 1 – 5 ), along with nine known sesquiterpene lactones ( 6 – 14 ) were isolated from the whole plant of Carpesium abrotanoides L. Their structures were elucidated on the basis of spectroscopic date, HRESIMS analysis, and comparison of experimental and calculated ECD data. All isolated compounds ( 1 – 14 ) were tested in vitro for their cytotoxic activities against the MDA-MB-231, HGC-27 cancer cell lines, of which compounds 1 – 3 , 6 , 7 , 11 and 12 showed significant cytotoxic activities with IC 50 values ranging from 2.67 to 12.34 μM. [ABSTRACT FROM AUTHOR]

• Composite propellants (CPs) containing insensitive high-energy qy-HMX have been prepared. • The qy-HMX-based CPs has 9.64% higher heat of explosion than HMX-based one. • The burn rate of CPs containing qy-HMX is 4.38 mm·s−1 at 3 MPa, 45.9% lower than that of corresponding HMX-based one. • The average particle size of the CCPs of qy-HMX-based CPs is 71.5% lower than that of HMX-based one. Two types of qy-HMX (insensitive HMX with improved energy density, numbered 1 and 2) have been used and studied as an ingredient of HTPB-based composite propellants (CPs), and the decomposition and combustion performances have been investigated. It has been shown that the main exothermic peak temperature of blank CPs containing 21 wt% of qy-HMX-1 is 258.9 °C, which is 4.7 °C higher than that of HMX-containing one, indicating improved thermostability. The corresponding heat of explosion for blank qy-HMX-2-based CPs was measured to be 5830 J∙g−1, which is 300 J∙g−1 higher than that of HMX-based one. Interestingly, the qy-HMX-2-based CPs has higher energy density than corresponding CL-20-based ones, but it has much lower burn rate under the same pressure, e.g. 4.38 mm∙s−1 at 3 MPa for the former vs. 9.03 mm∙s−1 for the latter. Under the effect of typical conventional catalysts such as nano-CuO and nano-Fe 2 O 3 , the qy-HMX-1-based CPs showed increased heat of explosion and higher burn rate. In addition, the particle sizes of condensed combustion products (CCPs) of CPs containing qy-HMX-2 are much smaller than that of HMX-based one, where the Al 4 C 3 was produced as its unique CCPs ingredient. [ABSTRACT FROM AUTHOR]