1. Re-infection with a different SARS-CoV-2 clade and prolonged viral shedding in a hematopoietic stem cell transplantation patient
- Author
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Amani H. Yamani, Abeer N. Alshukairi, Ashraf Dada, Ahmed A. Aljohaney, Intikhab Alam, Muhammad Yasir, Husam A. Bahaudden, Ahmed M. Tolah, Tagreed L. Alsubhi, Takashi Gojobori, Esam I. Azhar, Ahmed M. Hassan, Mohammed F. Saeedi, Sherif A. El-Kafrawy, Norah A. Othman, Naif I. AlJohani, Jaffar A. Al-Tawfiq, Aleksandar Radovanovic, Alimuddin Zumla, and Thamir A. Alandijany
- Subjects
Microbiology (medical) ,Whole genome sequencing ,2019-20 coronavirus outbreak ,SARS-CoV-2 ,business.industry ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,medicine.medical_treatment ,COVID-19 ,Infectious and parasitic diseases ,RC109-216 ,General Medicine ,Hematopoietic stem cell transplantation ,Re-infection ,medicine.disease ,Virology ,Lymphoma ,Prolonged viral shedding ,Infectious Diseases ,Hematological stem cell transplant ,Medicine ,Viral shedding ,business ,Clade ,Immunocompromised ,Re infection - Abstract
Immunocompromised patients who have a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection pose many clinical and public health challenges. We describe the case of a hematopoietic stem cell transplantation patient with lymphoma who had a protracted illness requiring three consecutive hospital admissions. Whole genome sequencing confirmed two different SARS-CoV-2 clades. Clinical management issues and the unanswered questions arising from this case are discussed.
- Published
- 2021