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Start Over Author "Argento, C." Publisher elsevier bv
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2. Normal serum concentrations of anti-Müllerian hormone in women with regular menstrual cycles

Author

Marca, A. L., Sighinolfi, G., Giulini, S., Traglia, M., Argento, C., Sala, C., Masciullo, C., Volpe, Annibale, Toniolo, D., and LA MARCA, Antonio

Subjects
Adult, Anti-Mullerian Hormone, Oral, Aging, endocrine system, medicine.medical_specialty, Adolescent, endocrine system diseases, Cross-sectional study, media_common.quotation_subject, European Continental Ancestry Group, Reproductive Endocrinology, Normal serum, White People, Reference Values, Internal medicine, medicine, Humans, Ovarian reserve, Contraceptives, Cross-Sectional Studies, Female, Menstrual Cycle, Middle Aged, Menstrual cycle, media_common, biology, urogenital system, business.industry, Obstetrics and Gynecology, Anti-Müllerian hormone, female genital diseases and pregnancy complications, Endocrinology, Reproductive Medicine, Ageing, biology.protein, business, hormones, hormone substitutes, and hormone antagonists, Contraceptives, Oral, Developmental Biology, Hormone
Abstract

Anti-Müllerian hormone (AMH) has become the 'molecule of the moment' in the field of reproductive endocrinology. Indeed, it is valuable as a means of increasing understanding of ovarian pathophysiology and for guiding clinical management across a broad range of conditions. However, no normative values have been established for circulating AMH in healthy women. In this cross-sectional study, 277 healthy females (aged 18-50 years) were included. AMH was measured by commercial enzyme-linked immunosorbent assay. Serum AMH concentrations show a progressive decline with female ageing. The age-related changes in AMH were best fitted by a polynomial function. Mean AMH concentrations were not modified by past use of oral contraceptive and were independent of parity of women. Age-specific normative values for circulating AMH concentration were established. AMH concentrations seem to be independent of the reproductive history of the patient.

Published
2010

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