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Your search keyword '"Braf protein"' showing total 2 results
Start Over Descriptor "Braf protein" Publisher elsevier bv
2 results on '"Braf protein"'

1. Small molecule inhibitors of BRAF in clinical trials

Author

Alfonso Zambon, Richard Marais, Ion Niculescu-Duvaz, Caroline J. Springer, and Dan Niculescu-Duvaz

Subjects
Proto-Oncogene Proteins B-raf, endocrine system diseases, Clinical Biochemistry, Pharmaceutical Science, Biology, Biochemistry, Clinical biochemistry, Structure-Activity Relationship, Drug Discovery, medicine, Humans, skin and connective tissue diseases, Melanoma, Protein Kinase Inhibitors, neoplasms, Molecular Biology, Clinical Trials as Topic, Organic Chemistry, BRAF Protein, BRAF protein, Clinical candidate, Kinase inhibitor, Molecular Weight, 3003, Drug Discovery3003 Pharmaceutical Science, Molecular Medicine, medicine.disease, Small molecule, digestive system diseases, Clinical trial, enzymes and coenzymes (carbohydrates), Cancer research
Abstract

Over the last few years, BRAF has emerged as a validated target in melanoma. This review summarises recent advances in the development of BRAF inhibitors, focussing on agents that have been assessed clinically.

Published
2012
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2. Molecular markers and biological targeted therapies in metastatic colorectal cancer: expert opinion and recommendations derived from the 11th ESMO/World Congress on Gastrointestinal Cancer, Barcelona, 2009

Author

Cutsem, E. Van, Dicato, M., Arber, N., Berlin, J., Cervantes, A., Ciardiello, F., Gramont, A. De, Diaz-Rubio, E., Ducreux, M., Geva, R., Glimelius, B., Glynne-Jones, R., Grothey, Axel, Gruenberger, T., Haller, D., Haustermans, K., Labianca, R., Lenz, H. J., Minsky, B., Nordlinger, B., Ohtsu, A., Pavlidis, Nicholas, Rougier, P., Schmiegel, W., Velde, C. Van de, Schmoll, H. J., Sobrero, A., Tabernero, Josep, and Pavlidis, Nicholas [0000-0002-2195-9961]

Subjects
Oncology, Colorectal cancer, medicine.medical_treatment, Braf protein, Gastroenterology, Metastasis, Drug antagonism, Targeted therapy, Antineoplastic agents, Pathology, Conference paper, Biological markers, Predictive marker, Hematology, Prognosis, Chemotherapy regimen, Antineoplastic agent, Proto-oncogene proteins, Ras protein, Human, Receptor, medicine.medical_specialty, Neoplasm metastasis, Ras proteins, MEDLINE, Oncoprotein, Colorectal neoplasms, Proto-oncogene proteins b-raf, Internal medicine, Genetics, medicine, Humans, Gastrointestinal cancer, Colorectal tumor, B raf kinase, Epidermal growth factor receptor, Kras protein, business.industry, Epidermal growth factor, Cancer, medicine.disease, digestive system diseases, Biological marker, Metabolism, Spain, Mutation, Carcinoembryonic antigen, Microsatellite instability, business
Abstract

The article summarizes the expert discussion and recommendations on the use of molecular markers and of biological targeted therapies in metastatic colorectal cancer (mCRC), as well as a proposed treatment decision strategy for mCRC treatment. The meeting was conducted during the 11th ESMO/World Gastrointestinal Cancer Congress (WGICC) in Barcelona in June 2009. The manuscript describes the outcome of an expert discussion leading to an expert recommendation. The increasing knowledge on clinical and molecular markers and the availability of biological targeted therapies have major implications in the optimal management in mCRC. 21 Suppl 6 vi1 10

Published
2010
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