1. Postoperative Mycobacteroides abscessus subsp. abscessus endophthalmitis: Clinical analysis of 12 clustered adults and a proposed therapeutic algorithm
- Author
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Sheng Min Hsu, Ching Lung Chen, Yu Ti Teng, Chun Chieh Lai, Jia Horung Hung, Chien Hsiung Lai, Fu Chin Huang, Chau Yin Chen, Shih Hao Wang, Po Lin Chen, Sung Huei Tseng, Cheng Lin Wu, Wen Chien Ko, Sheng Hsiang Lin, and Evelyn Jou Chen Huang
- Subjects
Male ,0301 basic medicine ,genetic structures ,medicine.medical_treatment ,lcsh:QR1-502 ,Vitrectomy ,Eye ,lcsh:Microbiology ,Postoperative Complications ,0302 clinical medicine ,Endophthalmitis ,Immunology and Allergy ,030212 general & internal medicine ,Stage (cooking) ,Aged, 80 and over ,Mycobacterium abscessus ,Clinical pathology ,Hazard ratio ,Nontuberculous Mycobacteria ,General Medicine ,Middle Aged ,Anti-Bacterial Agents ,Infectious Diseases ,medicine.anatomical_structure ,Female ,Algorithms ,Adult ,Microbiology (medical) ,Pars plana ,medicine.medical_specialty ,Adolescent ,030106 microbiology ,Taiwan ,Mycobacterium Infections, Nontuberculous ,Microbial Sensitivity Tests ,Young Adult ,03 medical and health sciences ,Clarithromycin ,medicine ,Humans ,Amikacin ,Aged ,General Immunology and Microbiology ,business.industry ,Cataract surgery ,medicine.disease ,Surgery ,Mycobacteroides abscessus subsp. abscessus ,Complication ,business - Abstract
Purpose: Postoperative endophthalmitis caused by nontuberculous mycobacterium is a rare but devastating complication after intraocular surgery. However, optimal treatment strategies remain undetermined in view of its rarity. Methods: We investigated the cases of culture-proven postoperative Mycobacteroides abscessus subsp. abscessus endophthalmitis in southern Taiwan, focusing on clinical manifestations and microbiological study, and aimed to describe clinical staging and to propose a therapeutic modality for this disease. Results: Twelve cases, including two published cases, were treated in two medical centers in southern Taiwan between Aug. 2011 and Dec. 2016, and all ever received cataract surgery at one clinic. Their disease courses could be categorized into four distinct stages, i.e., the initial, quiescent, recurrent, and end stage, and some cases experienced 1–4 cycles of quiescent-recurrent stages. Although all eyes ended up with phthisis or were eviscerated, the affected eyes receiving pars plana vitrectomy (PPV) tended to become quiescent and survived longer than those without PPV (adjusted hazard ratio: 13.9, p
- Published
- 2020
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