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1. Investigating the scope of pseudoproline assisted peptide cyclization

Author

Nima Sayyadi, Katrina A. Jolliffe, Samira Leesch, and Deni Taleski

Subjects
chemistry.chemical_classification, Pseudoproline, Chemistry, Organic Chemistry, Peptide, Biochemistry, Combinatorial chemistry, Cyclic peptide, Amino acid, Serine, Turn (biochemistry), chemistry.chemical_compound, Yield (chemistry), Drug Discovery, Threonine
Abstract

The cyclization of linear peptides from six to nine amino acids in length and containing between two and four pseudoproline turn inducers derived from serine or threonine was investigated to determine the effect of peptide length, amino acid composition and spacing between the pseudoproline residues on macrocyclization yield.

Published
2014
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