1. C O bond formation in a microfluidic reactor: high yield S N Ar substitution of heteroaryl chlorides
- Author
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Jesus Campagna, Patricia Spilman, Varghese John, Mohammad Parvez Alam, and Jagodzinska Barbara
- Subjects
Primary (chemistry) ,010405 organic chemistry ,Organic Chemistry ,Microfluidics ,Flow chemistry ,Bond formation ,010402 general chemistry ,01 natural sciences ,Biochemistry ,Combinatorial chemistry ,Article ,0104 chemical sciences ,Catalysis ,chemistry.chemical_compound ,chemistry ,Transition metal ,Yield (chemistry) ,Drug Discovery ,Organic chemistry ,Phenols - Abstract
This study describes our development of a novel and efficient procedure for C-O bond formation under mild conditions, for coupling heteroaryl chlorides with phenols or primary aliphatic alcohols. We utilized a continuous-flow microfluidic reactor for C-O bond formation in electron-deficient pyrimidines and pyridines in a much more facile manner with a cleaner reaction profile, high yield, quick scalability and without the need for the transition metal catalyst. This approach can be of general utility to make C-O bond containing intermediates of industrial importance in a continuous and safe manner.
- Published
- 2016
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