1. Sesquiterpenoids from the leaves of Sarcandra glabra
- Author
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Luo Jun, Wang Yong-Yue, Chi Jun, Kong Ling-yi, LI Ji-Xin, and LI Qiu-Rong
- Subjects
Plant Leaves ,Polycyclic Sesquiterpenes ,Molecular Structure ,Complementary and alternative medicine ,Traditional medicine ,Chemistry ,Seeds ,Drug Discovery ,Ic50 values ,General Medicine ,Sesquiterpenes ,Sarcandra glabra - Abstract
Sarglanoids A–F, six new sesquiterpenoids belonging to eudesmane ( 1 – 5 ) and eremophilane ( 6 ) types, were isolated from the leaves of Sarcandra glabra, a famous traditional Chinese medicine (TCM). Their structures including absolute configurations were elucidated through extensive spectroscopic analyses and electronic circular dichroism (ECD) calculations. Thereinto, compounds 1 – 2 were rare N-containing eudesmane-type sesquiterpenoids. Compound 3 exhibited inhibitory activity against nitric oxide (NO) production in lipopolysaccharides (LPS)-induced RAW 264.7 cells with IC50 values at 20.00 ± 1.30 μM. This research provides scientific basis for sesquiterpenoids as the medicinal material foundation of S. glabra.
- Published
- 2022