1. An antioxidant, N,N′-diphenyl-p-phenylenediamine (DPPD), affects labor and delivery in rats: A 28-day repeated dose test and reproduction/developmental toxicity test
- Author
-
Hiromasa Takashima, Atsushi Ono, Akihiko Hirose, Kazuhito Yokoyama, Mutsuko Hirata-Koizumi, Mariko Matsumoto, Makiko Yamaguchi, Hina Kato, Yuka Yoshida, Tomoko Kawamura, Mika Takahashi, and Mika Senuma
- Subjects
Male ,Antioxidant ,media_common.quotation_subject ,medicine.medical_treatment ,Developmental toxicity ,Phenylenediamines ,Pharmacology ,Toxicology ,Rats, Sprague-Dawley ,chemistry.chemical_compound ,Animal science ,Pregnancy ,Toxicity Tests ,medicine ,Animals ,Adverse effect ,media_common ,No-Observed-Adverse-Effect Level ,Dose-Response Relationship, Drug ,business.industry ,Body Weight ,Parturition ,p-Phenylenediamine ,General Medicine ,Hypothermia ,medicine.disease ,Rats ,chemistry ,Toxicity ,Pregnancy, Animal ,Female ,medicine.symptom ,Reproduction ,business ,Food Science - Abstract
A 28-day repeated dose toxicity test and reproduction/developmental toxicity test for N,N'-diphenyl-p-phenylenediamine (DPPD) were conducted in [Crl:CD(SD)] SPF rats. Male and female rats were dosed with DPPD by gavage for 28 days at 0, 100, 300, or 1000 mg/kg bw/day or for a total of 42-46 days at 0, 8, 50, or 300 mg/kg bw/day. No significant adverse effects were observed in the repeated dose toxicity study up to 1000 mg/kg bw/day in both sexes. In the reproduction/developmental toxicity study, two females showed piloerection, hypothermia, and pale skin; one died and the other showed dystocia on day 23 of pregnancy at 300 mg/kg bw/day. Another female delivered only three live pups at 300 mg/kg bw/day. A significantly prolonged gestation period was observed at 50 and 300 mg/kg bw/day. The NOAELs of repeated dose toxicity and reproduction/developmental toxicity were considered to be 1000 and 8 mg/kg bw/day, respectively.
- Published
- 2013
- Full Text
- View/download PDF