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4 results on '"O Patzer"'

1. New risk and protective factors for severe hypoglycaemia in people with type 1 diabetes

Author

Peter Kovacs, Andreas Holstein, T. Tiemann, Meinhard Mende, Tobias Wohland, C. Koch-Tessarek, O Patzer, and JD Holstein

Subjects
Blood Glucose, Male, Time Factors, Endocrinology, Diabetes and Metabolism, Medicine (miscellaneous), Kaplan-Meier Estimate, Severity of Illness Index, Nursing care, 0302 clinical medicine, Recurrence, Risk Factors, Germany, Odds Ratio, Insulin, 030212 general & internal medicine, Nutrition and Dietetics, Age Factors, Middle Aged, Treatment Outcome, Female, Cardiology and Cardiovascular Medicine, Risk assessment, Adult, medicine.medical_specialty, Drug Compounding, 030209 endocrinology & metabolism, Hypoglycemia, Risk Assessment, Drug Administration Schedule, 03 medical and health sciences, Home Health Nursing, Internal medicine, Diabetes mellitus, Severity of illness, medicine, Humans, Hypoglycemic Agents, Aged, Proportional Hazards Models, Retrospective Studies, Glycated Hemoglobin, Type 1 diabetes, business.industry, Odds ratio, Protective Factors, medicine.disease, Comorbidity, Nursing Homes, Diabetes Mellitus, Type 1, Logistic Models, Endocrinology, Multivariate Analysis, business, Biomarkers
Abstract

To evaluate risk factors for severe hypoglycaemia (SH) in patients with type 1 diabetes (T1DM).Retrospective observational and comparative study. All SH occurring between 2007 and 2014 in a German population (Lippe-Detmold) were captured. Characteristics of patients with T1DM and SH were compared with a control group being equivalent concerning age, diabetes duration, HbA1c, comorbidity, and β-blocker treatment. SH was defined as a symptomatic event requiring treatment with intravenous glucose or glucagon administration and being confirmed by a blood glucose measurement of

Published
2017

2. Accumulation of severe hypoglycemia at weekends and in warm seasons in patients with type 1 diabetes but not with type 2 diabetes

Author

Peter Kovacs, JD Holstein, Florian Trachte, O Patzer, Andreas Holstein, and Tobias Wohland

Subjects
Adult, Blood Glucose, Male, medicine.medical_specialty, endocrine system diseases, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Population, 030209 endocrinology & metabolism, Type 2 diabetes, 030204 cardiovascular system & hematology, Hypoglycemia, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, Germany, Internal medicine, Diabetes mellitus, Internal Medicine, medicine, Humans, Insulin, Prospective Studies, Prospective cohort study, education, Aged, Glycated Hemoglobin, education.field_of_study, Type 1 diabetes, business.industry, Incidence (epidemiology), nutritional and metabolic diseases, Middle Aged, medicine.disease, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Female, Seasons, business
Abstract

Aims To determine the influence of daytime, weekdays and seasons on the frequency of severe hypoglycemia (SH) in a German population. Methods Prospective population-based observational study capturing all episodes of SH between 2007 and 2014 in the Lippe-Detmold area. SH was defined as a symptomatic event requiring treatment with intravenous glucose or administration of glucagon and being confirmed by a blood glucose measurement of Results A total of 1080 episodes of SH in 747 patients were registered. 37.5% of cases (405/1080) were related to T1DM, 51.9% (561/1080) to T2DM, 3.2% (35/1080) to pancreatic diabetes and 7.3% (79/1080) to non-diabetic individuals. In cases with T1DM we observed a significantly higher event rate of SH at weekends versus the rest of the week: 2.87 events/weekend-hour versus 2.15 events/weekday-hour ( p =0.004), especially on Saturdays. We found significantly increased incidences of SH in spring (31.2%) and summer (26.7%) versus autumn (20.3%) and winter (21.8%). There were no corresponding significant seasonal variations of HbA1c and insulin doses. The seasonal distribution of SH in subjects with T2DM was balanced with no peak incidence at weekends. Conclusions For the risk of SH, time factors appear to contribute more substantially in individuals with T1DM than in patients with T2DM. The enhanced frequency of SH in patients with T1DM at weekends and in warm seasons was probably caused by short-term changes in behavior. Intensification of diabetes care and education with better adjustment of insulin doses in these susceptible periods could be an appropriate approach to prevent SH.

Published
2016

3. Response to Gentile S et al.: Risk factors for severe hypoglycaemia in people with insulin-treated diabetes: Are we sure we took into account all variables involved?

Author

Peter Kovacs, Andreas Holstein, Tobias Wohland, JD Holstein, and O Patzer

Subjects
Pediatrics, medicine.medical_specialty, Nutrition and Dietetics, business.industry, Endocrinology, Diabetes and Metabolism, Insulin, medicine.medical_treatment, MEDLINE, Medicine (miscellaneous), 030209 endocrinology & metabolism, 030204 cardiovascular system & hematology, Hypoglycemia, medicine.disease, 03 medical and health sciences, 0302 clinical medicine, Medicine, Cardiology and Cardiovascular Medicine, business, Insulin treated diabetes
Published
2017

4. PDB2 Considerably Increasing Incidence of Severe Hypoglycemia 2007-2010 Versus 1997-2000 – a German Longitudinal Population-Based Study

Author

K. Machalke, O Patzer, Andreas Holstein, F.W. Dippel, Peter Kovacs, and JD Holstein

Subjects
Pediatrics, medicine.medical_specialty, business.industry, Health Policy, Incidence (epidemiology), Public Health, Environmental and Occupational Health, Severe hypoglycemia, language.human_language, Surgery, German, Population based study, medicine, language, business
Published
2011

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