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Purpose: To build a radiomics model of liver contrast-enhanced computed tomography (CT) to predict hepatic encephalopathy secondary to Hepatitis B related cirrhosis., Materials and Methods: This study consisted of 304 consecutive patients with first-diagnosed hepatitis B related cirrhosis. 212 and 92 patients were randomly computer-generated into training and testing cohorts, among which 38 and 21 patients endured HE, respectively. 356 radiomics features of liver were extracted from portal venous-phase CT data, and 3 clinical features were collected from medical record. After data were standardized by Z-score, we used least absolute shrinkage and selection operator to choose useful radiomics features. Ultimately, three predictive models including a radiomics model, a clinical model and an integrated model of radiomics and clinical features were built by analysis of R-software. Predictive performance was tested by multivariable logistic regression, and evaluated by area under receiver-operating characteristic curve (AUC), and accuracy., Results: 19 radiomics features of liver CT were selected. The selected radiomics features and 3 relevant clinical features were applied to develop a radiomics model, a clinical model, and an integrated model of both radiomics and clinical features. The integrated model showed better performance than the radiomics model or clinical model to predict HE (AUC = 0.94 vs. 0.91 or 0.76, and 0.87 vs. 0.86 or 0.73; accuracy = 0.93 vs. 0.89 or 0.83, and 0.83 vs. 0.84 or 0.77) in the training and testing cohorts, respectively., Conclusion: The integrated model of radiomics and clinical features could well predict HE secondary to hepatitis B related cirrhosis., (Copyright © 2020 Elsevier B.V. All rights reserved.)

Purpose: To determine whether gross tumour volume (GTV) of adenocarcinoma of oesophagogastric junction (AOG) measured on fat-suppression T 2 -weighted imaging (FS-T 2 WI) and diffusion-weighted imaging (DWI) correlates with regional lymph node metastasis and N stage., Materials and Methods: The study was approved by the institutional ethics committee, and written informed consent was obtained. Forty-six patients with AOG underwent preoperative magnetic resonance scans including FS-T 2 WI and DWI with b-values of 500 and 800 s/mm 2 . GTV was measured on FS-T 2 WI and DWI. Statistical analyses were performed to determine association of GTV with N stage., Results: Univariate analysis showed GTV measured on FS-T 2 WI and DWI with b-values of 500 and 800 s/mm 2 were correlated with lymph node metastasis (all Ps < 0.05). Spearman rank correlation tests demonstrated a trend toward an increase in GTV obtained on previous sequences with increasing N stage (r = 0.578 to 0.591, all Ps < 0.001). Mann-Whitney U tests showed GTV obtained on previous sequences could distinguish grouped N stages (all Ps < 0.05). Receiver operating curve analyses demonstrated that GTV obtained on FS-T 2 WI and DWI with b-value of 500 s/mm 2 and DWI with b-value of 800 s/mm 2 might differentiate stage N0 from stages N1-3 (cutoff, 19.70 cm 3 , 16.70 cm 3 and 12.24 cm 3 , respectively), stages N0-1 from N2-3 (cutoff: 22.16 cm 3 , 17.54 cm 3 and 14.17 cm 3 , respectively), stages N0-2 from N3 (cutoff: 25.57 cm 3 , 29.27 cm 3 and 22.73 cm 3 , respectively)., Conclusion: There is a trend toward an increase in GTV obtained on FS-T 2 WI and DWI sequences with increasing N stage., (Copyright © 2018 Elsevier B.V. All rights reserved.)