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Your search keyword '"C, Thurieau"' showing total 2 results
Start Over Author "C, Thurieau" Publisher elsevier science ltd
2 results on '"C, Thurieau"'

1. Novel non-peptide ligands for the somatostatin sst3 receptor.

Author

Moinet C, Contour-Galcéra MO, Poitout L, Morgan B, Gordon T, Rouber P, and Thurieau C

Subjects
Amides chemical synthesis, Animals, Binding Sites physiology, CHO Cells, Cricetinae, Cyclic AMP analysis, Cyclic AMP biosynthesis, Dose-Response Relationship, Drug, Humans, Imidazoles chemical synthesis, Imidazoles pharmacology, Ligands, Nitrobenzenes chemical synthesis, Protein Binding physiology, Recombinant Proteins antagonists & inhibitors, Amides pharmacology, Colforsin pharmacology, Cyclic AMP agonists, Nitrobenzenes pharmacology, Receptors, Somatostatin antagonists & inhibitors, Somatostatin pharmacology
Abstract

A series of imidazole derivatives has been prepared using high throughput parallel synthesis. Several compounds showed high affinity (Ki in 10(-6)-10(-8) M range) and selectivity at recombinant human somatostatin receptor subtype 3 (hsst3).

Published
2001
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2. Synthesis of substituted imidazopyrazines as ligands for the human somatostatin receptor subtype 5.

Author

Contour-Galéra MO, Poitout L, Moinet C, Morgan B, Gordon T, Roubert P, and Thurieau C

Subjects
Animals, CHO Cells, Combinatorial Chemistry Techniques, Cricetinae, Humans, Imidazoles chemistry, Imidazoles pharmacology, Ligands, Molecular Structure, Protein Binding, Protein Isoforms metabolism, Pyrazines chemistry, Pyrazines pharmacology, Receptors, Somatostatin agonists, Receptors, Somatostatin chemistry, Imidazoles chemical synthesis, Imidazoles metabolism, Pyrazines chemical synthesis, Pyrazines metabolism, Receptors, Somatostatin metabolism
Abstract

A new preparation of trisubstituted imidazopyrazines and dihydroimidazopyrazines via parallel synthesis using aminoacids and bromoketones resulted in the discovery of non-peptidic sst5 selective agonists.

Published
2001
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