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1. Exploration of beta-turn scaffolding motifs as components of sialyl Le(X) mimetics and their relevance to P-selectin.

Author

Hanessian S, Huynh HK, Reddy GV, McNaughton-Smith G, Ernst B, Kolb HC, Magnani J, and Sweeley C

Subjects
Binding, Competitive, Carbohydrate Conformation, Carbohydrate Sequence, E-Selectin metabolism, Indolizines chemistry, Molecular Sequence Data, Oligosaccharides chemistry, Sialyl Lewis X Antigen, Structure-Activity Relationship, Substrate Specificity, beta-Lactams chemistry, Indolizines chemical synthesis, Indolizines metabolism, Oligosaccharides chemical synthesis, Oligosaccharides metabolism, P-Selectin metabolism, beta-Lactams chemical synthesis, beta-Lactams metabolism
Abstract

Monocyclic and bicyclic lactam units representing beta-turn surrogates were incorporated into a sialyl Le(X) structure by replacement of the natural sugar components. Low micromolar activity was found in a new P-selectin binding assay.

Published
1998
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