1. Unlocking the biosynthesis of psychedelic-inspired indolethylamines.
- Author
-
Sen AK and Jones JA
- Subjects
- N,N-Dimethyltryptamine, Hallucinogens pharmacology
- Abstract
A recent report by Chen et al. describes the discovery of RmNMT, a highly active and promiscuous tryptamine N-methyltransferase from the cane toad, Rhinella marina. N,N-dimethyltryptamine derivatives produced by this enzyme were then evaluated for their potential to serve as next-generation treatments for mental health disorders., Competing Interests: Declaration of interests J.A.J. is significant stakeholder at PsyBio Therapeutics, which has licensed tryptamine biosynthesis-related technology from Miami University. J.A.J. and A.K.S. are inventors on several related patent applications., (Copyright © 2023 Elsevier Ltd. All rights reserved.)
- Published
- 2024
- Full Text
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