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OBJECTIVE:To investigate the status of detection and drug resistance of Mycoplasma in outpatients with genitourinary system infection in Henan Provincial Hospital( hereinafter referred to as “ our hospital”,so as to provide theoretical basis for clinical diagnosis and treatment. METHODS:Retrospective statistical analysis was carried out on the culture and drug sensitive results of Mycoplasma test in patients with genitourinary system infection in our hospital in 2018. Mycoplasma culture and in vitro drug sensitivity test results of 850 outpatients with genitourinary system infection in our hospital in 2018 were analyzed retrospectively. RESULTS:Among the 850 patients,523 cases were positive for Mycoplasma, with a Mycoplasma carriage rate of 61. 53%, of which the single positive rates for Ureaplasma urealyticum(UU) and Mycoplasma hominis ( MH) were respectively 49. 18% ( 418 cases) and 2. 12% (18 cases),and the rate of mixed infections was 10. 24%(87 cases). Mycoplasma was more sensitive to doxycycline, minocycline hydrochloride,tetracycline,coxsamine and clarithromycin,with sensitivity rates of 86. 42%(452 cases), 83. 37%(436 cases),80. 69%(422 cases),70. 94%(371 cases) and 70. 75%(370 cases),respectively. Mycoplasma had high resistance rates to ciprofloxacin, azithromycin, roxithromycin, sparfloxacin and levofloxacin,with resistance rates of 81. 64% ( 427 cases), 71. 32% ( 373 cases), 66. 92% ( 350 cases), 53. 35% ( 279 cases) and 48. 95% (256 cases), respectively. Mycoplasma resistance rates were generally higher in UU-infected patients with UU counts ≥10 4 than in those with UU counts <10 4. Mycoplasma resistance rates were the highest in those with mixed infections of the two kinds of Mycoplasma,followed by those with MH infection,and lower in those with UU infection. CONCLUSIONS:Mycoplasma carriage rate among outpatients with genitourinary infection was high and dominated by UU infection,followed by mixed UU and MH infection. Doxycycline,minocycline hydrochloride and tetracycline are recommended for empirical clinical treatment,while Mycoplasma culture and drug sensitivity tests need to be performed on suspected infected patients to reduce the emergence of drug-resistant strains. [ABSTRACT FROM AUTHOR]

OBJECTIVE: To probe into the efficacy of Valsartan capsules combined with Huangkui capsules in treatment of chronic glomerulonephritis. METHODS: 60 patients with chronic glomerulonephritis admitted into Xiaogan Central Hospital Affiliated to Wuhan University of Science and Technology from Aug. 2014 to Aug. 2015 were selected to be divided into observation group and control group via the random number table, with 30 cases in each. The control group were treated with valsartan, while the control group additionally received Huangkui capsules based on the control group. Changes of various indicators of two groups were compared, the clinical efficacy and incidence of adverse drug reactions were observed. RESULTS: After treatment, the urea nitrogen, 24 hour urinary protein, serum creatinine, triglyceride and total cholesterol in patients with chronic glomerulonephritis in observation group were better than those of control group, with statistically significant difference( P < 0. 05 ). The total effective rate of observation group was higher than that of control group, yet the incidence of adverse drug reactions was lower than that of control group, with statistically significant difference ( P <0.05). CONCLUSIONS: The efficacy of Valsartan capsules combined with Huangkui capsules in treatment of chronic glomerulonephritis is remarkable, which can improve patients’ renal function with few adverse drug reactions and high safety. [ABSTRACT FROM AUTHOR]

OBJECTIVE: To probe into the clinical effects of Shensongyangxin capsules combined with metoprolol tartrate in treatment of ventricular premature coronary heart disease. METHODS: 122 patients with ventricular premature coronary heart disease admitted into Xiaogan Central Hospital Affiliated to Wuhan University of Science and Technology from Sept. 2013 to Nov. 2015 were selected to be divided into observation group and control group via the random number table, with 61 cases in each. The control group were given Xinlvning tablets, while the observation group were treated with Shensongyangxin capsules combined with metoprolol tartrate. The efficacy of ventricular premature beat,times of ventricular premature beat, efficacy of TCM syndromes and total score of TCM syndromes of two groups were observed. RESULTS: The total effective rate of ventricular premature beat in observation group was 77. 05% (47/61), significantly higher than that in control group [59. 02% (36/61) ]. After treatment, times of ventricular premature beat and total score of TCM syndromes in observation group were significantly lower than those in control group. The total effective rate of TCM syndromes of observation group was 85. 25% (52/61), significantly higher than that of control group [68. 85% (42/61) ], with statistically significant difference (P < 0. 05). CONCLUSIONS: The effects of Shensongyangxin capsules combined with metoprolol in treatment of ventricular premature coronary heart disease is significant, which can effectively improve the TCM syndromes in patients. [ABSTRACT FROM AUTHOR]