1. Effect of medroxyprogesterone acetate on thyrotropin secretion in adult and old female rats
- Author
-
Patricia Cristina Lisboa, C. C. Pazos-Moura, P.P. Borges, Egberto Gaspar de Moura, F. H. Curty, and R.M. Moreira
- Subjects
endocrine system ,medicine.medical_specialty ,endocrine system diseases ,Physiology ,medicine.drug_class ,Medroxyprogesterone ,Immunology ,Radioimmunoassay ,Biophysics ,Thyrotropin-releasing hormone ,progesterone ,Biology ,Biochemistry ,thyrotropin ,In vivo ,Internal medicine ,medicine ,Animals ,Medroxyprogesterone acetate ,General Pharmacology, Toxicology and Pharmaceutics ,lcsh:QH301-705.5 ,Analysis of Variance ,medroxyprogesterone acetate ,lcsh:R5-920 ,Progesterone Congeners ,General Neuroscience ,aging ,Age Factors ,Cell Biology ,General Medicine ,Androgen ,Rats ,ovariectomy ,Endocrinology ,lcsh:Biology (General) ,Case-Control Studies ,Pituitary Gland ,Ovariectomized rat ,Female ,lcsh:Medicine (General) ,thyrotropin-releasing hormone ,hormones, hormone substitutes, and hormone antagonists ,Glucocorticoid ,medicine.drug ,Hormone - Abstract
Steroid hormones have been implicated in the modulation of TSH secretion; however, there are few and controversial data regarding the effect of progesterone (Pg) on TSH secretion. Medroxyprogesterone acetate (MPA) is a synthetic alpha-hydroxyprogesterone analog that has been extensively employed in therapeutics for its Pg-like actions, but that also has some glucocorticoid and androgen activity. Both hormones have been shown to interfere with TSH secretion. The objective of the present study was to investigate the effects of MPA or Pg administration to ovariectomized (OVX) rats on in vivo and in vitro TSH release and pituitary TSH content. The treatment of adult OVX rats with MPA (0.25 mg/100 g body weight, sc, daily for 9 days) induced a significant (P
- Published
- 2000
- Full Text
- View/download PDF