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Your search keyword '"Vlasveld LT"' showing total 3 results
Start Over Author "Vlasveld LT" Publisher ferrata storti foundation
3 results on '"Vlasveld LT"'

2. Hb Bronovo, a new globin gene mutation at alpha2 103 (His->Leu) associated with an alpha thalassemia phenotype.

Author

Harteveld CL, Steen G, Vlasveld LT, van Delft P, and Giordano PC

Subjects
Adult, Family Health, Female, Globins genetics, Humans, Turkey, Hemoglobins, Abnormal genetics, Mutation, Missense, alpha-Thalassemia genetics
Abstract

Mild alpha-thalassemia, a common condition in many ethnic groups, presents with hematologic abnormalities almost identical to those found in iron deficiency. We report a new alpha globin chain variant associated with an alpha-thalassemia phenotype in two members of a Turkish family.

Published
2006

3. Hyperhomocysteinemia and functional cobalamin deficiency due to granulocytosis-induced alterations in the cobalamin-binding protein.

Author

Vlasveld LT, Bos GM, Ermens AA, Bakker JA, and Lindemans J

Subjects
Granulocyte Colony-Stimulating Factor therapeutic use, Humans, Leukemia, Myelogenous, Chronic, BCR-ABL Positive blood, Leukemia, Myelogenous, Chronic, BCR-ABL Positive drug therapy, Hyperhomocysteinemia blood, Transcobalamins metabolism, Vitamin B 12 analogs & derivatives, Vitamin B 12 blood, Vitamin B 12 Deficiency blood
Abstract

Serum cobalamin and homocysteine levels were studied in patients with chronic myelogenous leukemia (CML) and in stem cell donors treated with granulocyte-colony stimulating factor (G-CSF). Cytoreductive treatment in patients with CML resulted in a decrease of cobalamin and homocysteine levels. In stem cell donors cobalamin and homocysteine levels increased after G-CSF administration. The increase of homocysteine level was accompanied by a decrease in the serum levels of the cobalamin-binding protein transcobalamin. We hypothesize that the increased homocysteine levels in patients with CML and donors treated with G-CSF may be the result of a functional methylcobalamin deficiency due to decreased transcobalamin levels.

Published
2006

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