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Additional file 2. Full-length original western blots of PDK4 protein and MAPK/ERK-related protein was detected by western blot analysis include multiple exposures (Reh and HAL-01 cell lines).

Additional file 1: Supplementary data for some experiments. Fig. S1. Identification of 1,5-AG metabolite by liquid chromatography and mass spectrometry (LC-MS). Fig. S2. Effects of different concentrations of vitamin C on pre-B ALL cell viability (A) and apoptosis (B). 0.2 mM vitamin C was chosen as the intervention concentration. (C) Effects of 1,5-AG with 0.2 mM Vitamin C on cell cycle. Data are represented as mean ± SD; *p < 0.05, **p < 0.01, ***p < 0.001. Fig. S3. The infiltration of leukemia cells in BM (A) and spleen (B) for different groups on day 7 was analyzed by flow cytometry. Data were shown as mean ± SD (n = 5/group); ns (p ≥ 0.05); *p < 0.05; **p < 0.01. Table S1. Basic clinical characteristics of the patients.