1. Mast cell sarcoma of the scalp: the first sign of undisclosed systemic mastocytosis?
- Author
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Falleti J, Borgia L, Lalinga AV, De Cecio R, Natella V, Patitucci G, and Vita G
- Subjects
- Biomarkers, Tumor metabolism, DNA Mutational Analysis, DNA, Neoplasm analysis, Diagnosis, Differential, Female, Head and Neck Neoplasms etiology, Head and Neck Neoplasms metabolism, Head and Neck Neoplasms surgery, Humans, Mast-Cell Sarcoma etiology, Mast-Cell Sarcoma metabolism, Mast-Cell Sarcoma surgery, Mastocytosis, Systemic complications, Mastocytosis, Systemic metabolism, Middle Aged, Mutation, Proto-Oncogene Proteins c-kit genetics, Proto-Oncogene Proteins c-kit metabolism, Skin Neoplasms etiology, Skin Neoplasms metabolism, Skin Neoplasms surgery, Head and Neck Neoplasms diagnosis, Mast Cells pathology, Mast-Cell Sarcoma diagnosis, Mastocytosis, Systemic diagnosis, Scalp, Skin Neoplasms diagnosis
- Abstract
Mastocytosis is a neoplastic disease of mast cells and their CD34+ precursors, including a heterogeneous group of disorders. It is characterized by abnormal growth and accumulation of mast cells in one or more organ systems. Mast cell sarcoma is an extremely rare and aggressive disease characterized by local proliferation of atypical mast cells, destructive growth and poor prognosis, without systemic involvement. Very few clinical cases describing this entity have been reported in the literature. In this paper, we report a case of a mast cell sarcoma, localized in the scalp of a 63-year-old woman; it appears to be the first manifestation of undisclosed systemic mastocytosis., (Copyright © 2012 Elsevier GmbH. All rights reserved.)
- Published
- 2012
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