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1. Estimation of subject coregistration errors during multimodal preclinical imaging using separate instruments: origins and avoidance of artifacts

Author

Isabelle Duluc, Gaëlle Aubertin-Kirch, Jean-Noël Freund, Jean-Philippe Dillenseger, André Constantinesco, Chris Healy, Amira Sayeh, Christian Goetz, Philippe Choquet, Imagerie Préclinique-UF6237, Pôle d'imagerie [Strasbourg], Les Hôpitaux Universitaires de Strasbourg (HUS), Laboratoire des sciences de l'ingénieur, de l'informatique et de l'imagerie (ICube), École Nationale du Génie de l'Eau et de l'Environnement de Strasbourg (ENGEES)-Université de Strasbourg (UNISTRA)-Institut National des Sciences Appliquées - Strasbourg (INSA Strasbourg), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS)-Matériaux et nanosciences d'Alsace (FMNGE), Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique, Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA), Fédération de Médecine Translationnelle de Strasbourg (FMTS), Université de Strasbourg (UNISTRA), Klinik für Nuklear Medizin [Freiburg], Universitätsklinikum, King‘s College London, Equipe 1 'Emergence des Cellules Souches & Initiation Tumorale' (Groupe 2 : Hématopoïse et Leucémogenèse Humaines) (SMART - Inserm U1113), Interface de Recherche Fondamentale et Appliquée en Cancérologie (IRFAC - Inserm U1113), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Paul Strauss : Centre Régional de Lutte contre le Cancer (CRLCC)-Fédération de Médecine Translationelle de Strasbourg (FMTS)-Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Paul Strauss : Centre Régional de Lutte contre le Cancer (CRLCC)-Fédération de Médecine Translationelle de Strasbourg (FMTS), Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratoire de neurobiologie et pharmacologie cardiovasculaire (LNPCV), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut National de Recherche en Informatique et en Automatique (Inria)-Les Hôpitaux Universitaires de Strasbourg (HUS)-Centre National de la Recherche Scientifique (CNRS)-Matériaux et Nanosciences Grand-Est (MNGE), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique, Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Paul Strauss : Centre Régional de Lutte contre le Cancer (CRLCC)-Fédération de Médecine Translationelle de Strasbourg (FMTS), and Freund, Jean-Noël

Subjects
[SDV.IB] Life Sciences [q-bio]/Bioengineering, Multimodal imaging, Landmark, business.industry, Image Perception, Observer Performance, and Technology Assessment, [SDV]Life Sciences [q-bio], Target acquisition, 030218 nuclear medicine & medical imaging, [SDV] Life Sciences [q-bio], 03 medical and health sciences, 0302 clinical medicine, Error analysis, 030220 oncology & carcinogenesis, Medicine, Radiology, Nuclear Medicine and imaging, Computer vision, [SDV.IB]Life Sciences [q-bio]/Bioengineering, Artificial intelligence, Sources of error, Fiducial marker, business, Image resolution, Preclinical imaging
Abstract

International audience; We use high-resolution [Formula: see text] data in multiple experiments to estimate the sources of error during coregistration of images acquired on separate preclinical instruments. In combination with experiments with phantoms, we completed in vivo imaging on mice, aimed at identifying the possible sources of registration errors, caused either by transport of the animal, movement of the animal itself, or methods of coregistration. The same imaging cell was used as a holder for phantoms and animals. For all procedures, rigid coregistration was carried out using a common landmark coregistration system, placed inside the imaging cell. We used the fiducial registration error and the target registration error to analyze the coregistration accuracy. We found that moving an imaging cell between two preclinical devices during a multimodal procedure gives an error of about [Formula: see text] at most. Therefore, it could not be considered a source of coregistration errors. Errors linked to spontaneous movements of the animal increased with time, to nearly 1 mm at most, excepted for body parts that were properly restrained. This work highlights the importance of animal intrinsic movements during a multiacquisition procedure and demonstrates a simple method to identify and quantify the sources of error during coregistration.

Published
2017
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2. MSCT versus CBCT: Evaluation of high-resolution acquisition modes for dento-maxillary and skull-base imaging

Author

Catherine-Isabelle Gros, André Constantinesco, Jean-François Matern, Philippe Choquet, Fabien Bornert, Jean-Philippe Dillenseger, Jean-Marie Le Minor, Christian Goetz, Laboratoire des sciences de l'ingénieur, de l'informatique et de l'imagerie (ICube), École Nationale du Génie de l'Eau et de l'Environnement de Strasbourg (ENGEES)-Université de Strasbourg (UNISTRA)-Institut National des Sciences Appliquées - Strasbourg (INSA Strasbourg), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut National de Recherche en Informatique et en Automatique (Inria)-Les Hôpitaux Universitaires de Strasbourg (HUS)-Centre National de la Recherche Scientifique (CNRS)-Matériaux et Nanosciences Grand-Est (MNGE), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique, and Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Diagnostic Imaging, medicine.medical_specialty, Cone beam computed tomography, Multidetector Computed Tomography, Maxilla, medicine, Humans, Radiology, Nuclear Medicine and imaging, Computed tomography laser mammography, Image-guided radiation therapy, Neuroradiology, Skull Base, Phantoms, Imaging, business.industry, Reproducibility of Results, Industrial computed tomography, General Medicine, [PHYS.MECA]Physics [physics]/Mechanics [physics], Cone-Beam Computed Tomography, Skull, medicine.anatomical_structure, Otorhinolaryngology, Radiology, Tomography, business, Nuclear medicine, Tomography, Spiral Computed, Tooth
Abstract

Our aim was to conduct a quantitative and qualitative evaluation of high-resolution skull-bone imaging for dentistry and otolaryngology using different architectures of recent X-ray computed tomography systems.Three multi-slice computed tomography (MSCT) systems and one Cone-beam computed tomography (CBCT) system were used in this study. All apparatuses were tested with installed acquisition modes and proprietary reconstruction software enabling high-resolution bone imaging. Quantitative analyses were performed with small fields of view with the preclinical vmCT phantom, which permits to measure spatial resolution, geometrical accuracy, linearity and homogeneity. Ten operators performed visual qualitative analyses on the vmCT phantom images, and on dry human skull images.Quantitative analysis showed no significant differences between protocols in terms of linearity and geometric accuracy. All MSCT systems present a better homogeneity than the CBCT. Both quantitative and visual analyses demonstrate that CBCT acquisitions are not better than the collimated helical MSCT mode.Our results demonstrate that current high-resolution MSCT protocols could exceed the performance of a previous generation CBCT system for spatial resolution and image homogeneity.• Quantitative evaluation is a prerequisite for comparison of imaging equipment. • Bone imaging quality could be objectively assessed with a phantom and dry skull. • The current MSCT shows better image quality than a dental CBCT system. • CBCT remains a work-in-progress technology.

Published
2015
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3. Flow and Particles Deposition in Rabit and Rat Airways Under Realistic Inflow Rate

Author

Marianna Braza, Stephen Dubsky, D. Lo Jacono, S. Saintlos-Brillac, Y. Hoarau, Franck Plouraboué, Christian Goetz, Philippe Choquet, Andreas Fouras, Laboratoire des sciences de l'ingénieur, de l'informatique et de l'imagerie (ICube), Institut National des Sciences Appliquées - Strasbourg (INSA Strasbourg), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)-École Nationale du Génie de l'Eau et de l'Environnement de Strasbourg (ENGEES)-Réseau nanophotonique et optique, Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Matériaux et nanosciences d'Alsace (FMNGE), Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), École Nationale du Génie de l'Eau et de l'Environnement de Strasbourg (ENGEES)-Université de Strasbourg (UNISTRA)-Institut National des Sciences Appliquées - Strasbourg (INSA Strasbourg), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut National de Recherche en Informatique et en Automatique (Inria)-Les Hôpitaux Universitaires de Strasbourg (HUS)-Centre National de la Recherche Scientifique (CNRS)-Matériaux et Nanosciences Grand-Est (MNGE), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique, and Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Physics, Work (thermodynamics), 010504 meteorology & atmospheric sciences, business.industry, Flow (psychology), Fluid mechanics, Inflow, Mechanics, [PHYS.MECA]Physics [physics]/Mechanics [physics], Computational fluid dynamics, 01 natural sciences, 010305 fluids & plasmas, 0103 physical sciences, Deposition (phase transition), business, Inflow rate, Simulation, 0105 earth and related environmental sciences, Particle deposition
Abstract

The understanding of the flow structures and the particle transport/deposition across the human bronchial system remains a challenge to achieve because of the complexity of the geometry of human lungs. This work relies a strong collaboration between physicians, medical imaging researchers, fluid mechanics researcher and CFD researchers. Four configurations of airways (the generic Weibel model, the Human model proposed by Hiroko Kitaoka, a realistic Rat lung obtained by \(\mu \)-CT and a realistic rabbit geometry obtained by a synchrotron based CT) have been generated, meshed and simulated using the CFD commercial package CFD-ACE. Both steady and realistic inflow rates have been studied as well as the associated transport and deposition of particles.

Published
2013
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4. Mesure par µTDM et dilution de nanocolloïdes-99mTc de la surface péritonéale chez le rat insuffisant rénal au cours d'une expérience de dialyse péritonéale

Author

A. Constantinesco, Christian Goetz, M. Fischbach, C. Dheu, Philippe Choquet, Gaëlle Aubertin, Service de Biophysique et Médecine Nucléaire, CHU Strasbourg-Université Louis Pasteur - Strasbourg I-Hôpital de Hautepierre [Strasbourg], Service de pédiatrie, Hôpital de Hautepierre [Strasbourg], neurospin institut d'imagerie biomédicale, and Commissariat à l'énergie atomique et aux énergies alternatives (CEA)

Subjects
Gynecology, medicine.medical_specialty, Chemistry, Biomedical Engineering, Biophysics, medicine, [SPI.MECA.BIOM]Engineering Sciences [physics]/Mechanics [physics.med-ph]/Biomechanics [physics.med-ph], [PHYS.MECA.BIOM]Physics [physics]/Mechanics [physics]/Biomechanics [physics.med-ph], ComputingMilieux_MISCELLANEOUS
Abstract

Resume La dialyse peritoneale occupe une place importante dans la prise en charge de l’insuffisance renale au stade terminal, notamment chez le jeune enfant. L’optimisation de son efficacite necessite l’emploi de solutions de dialyse biocompatibles mais aussi l’amelioration du recrutement de la surface peritoneale d’echange (SPE). Les modeles experimentaux animaux sont une etape essentielle pour mesurer la SPE. Nous proposons une methode, rapide, de mesure in vivo de la SPE chez le rat a l’aide de donnees de microtomodensitometrie (μTDM) et a partir de la mesure du volume de dialysat obtenu par dilution isotopique de nanocolloides-99mTc.

Published
2009
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5. Explorations cardiologiques nucléaires dans la cardiomyopathie de Takotsubo

Author

Sébastien Cimarelli, Frédérique Sauer, Cyrille Blondet, Dorra Ben Sellem, Alessio Imperiale, Christian Goetz, André Constantinesco, Olivier Morel, Patrick Ohlmann, Service de Biophysique et Médecine Nucléaire, CHU Strasbourg-Université Louis Pasteur - Strasbourg I-Hôpital de Hautepierre [Strasbourg], Service de cardiologie, Hôpitaux Universitaires de Strasbourg, and Remond, Yves

Subjects
Gynecology, medicine.medical_specialty, Radiological and Ultrasound Technology, business.industry, [SPI.MECA.BIOM] Engineering Sciences [physics]/Mechanics [physics.med-ph]/Biomechanics [physics.med-ph], Biophysics, medicine, [PHYS.MECA.BIOM] Physics [physics]/Mechanics [physics]/Biomechanics [physics.med-ph], [SPI.MECA.BIOM]Engineering Sciences [physics]/Mechanics [physics.med-ph]/Biomechanics [physics.med-ph], Radiology, Nuclear Medicine and imaging, [PHYS.MECA.BIOM]Physics [physics]/Mechanics [physics]/Biomechanics [physics.med-ph], business, ComputingMilieux_MISCELLANEOUS
Abstract

Resume La cardiomyopathie de Takotsubo (CTT), decrite initialement au debut des annees 1990, represente 1 a 2 % des evenements cardiaques aigus et fait partie des diagnostics differentiels du syndrome coronarien aigu (SCA). Les examens isotopiques suivants : tomoscintigraphie myocardique au 201Tl (ou 99mTc-tetrofosmine), a la 123I-meta-IodoBenzyl-Guanidine (123I-mIBG) et tomographie par emission de positons (TEP)-tomodensitometrie (TDM) au 18F-flurodesoxyglucose (FDG) ont permis respectivement l’etude de la perfusion, de l’innervation et du metabolisme ventriculaire gauche (VG) afin d’evaluer l’apport de ces techniques chez des patients atteints de CTT. Dans les 15 jours suivant le declenchement de la maladie, quatre patients ont beneficie d’une tomoscintigraphie myocardique de perfusion et d’une tomoscintigraphie myocardique a la 123I-mIBG. Un TEP-FDG cardiaque a aussi ete realise chez deux d’entre eux. Nous avons reevalue l’innervation et le metabolisme myocardique trois mois et plus de six mois apres la phase aigue et compare le niveau de fixation des radionucleides. La perfusion du VG etait normale chez tous les patients, alors que l’examen a la 123I-mIBG et le TEP-FDG cardiaque montraient en phase subaigue une hypofixation apicale. L’association d’une perfusion normale et d’un metabolisme glucidique altere etait en faveur d’un aspect de « discordance inverse » entre la perfusion et le metabolisme dans la region apicale du VG. Les anomalies de fixation initiales de la 123I-mIBG et du FDG tendaient a se normaliser sur les examens ulterieurs. Les resultats ont montre la part neurogene preponderante dans l’etat de sideration myocardique apicale definissant la CTT. La tomoscintigraphie myocardique a la 123I-mIBG est l’examen a retenir pour eliminer plus facilement ce diagnostic parmi les diagnostics differentiels de SCA.

Published
2008

6. SPECT low-field MRI system for small-animal imaging

Author

Philippe Choquet, André Constantinesco, Elodie Breton, Christian Goetz, Vincent Israel-Jost, Service de Biophysique et Médecine Nucléaire, CHU Strasbourg-Université Louis Pasteur - Strasbourg I-Hôpital de Hautepierre [Strasbourg], Institut de Mécanique des Fluides et des Solides (IMFS), École Nationale du Génie de l'Eau et de l'Environnement de Strasbourg (ENGEES)-Centre National de la Recherche Scientifique (CNRS), Institut d'Histoire et de Philosophie des Sciences et des Techniques (IHPST), Université Paris 1 Panthéon-Sorbonne (UP1)-Département d'Etudes Cognitives - ENS Paris (DEC), École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-École normale supérieure - Paris (ENS Paris), and Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Materials science, [SDV]Life Sciences [q-bio], Mice, Nude, Kidney, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, Mice, 0302 clinical medicine, Small animal, Focal length, Animals, Radiology, Nuclear Medicine and imaging, Whole Body Imaging, Lung, ComputingMilieux_MISCELLANEOUS, Tomography, Emission-Computed, Single-Photon, business.industry, Phantoms, Imaging, Brain, Technetium, Low field mri, Magnetic Resonance Imaging, Thallium Radioisotopes, 030220 oncology & carcinogenesis, Dynamic contrast-enhanced MRI, Acquisition time, Pinhole (optics), Molecular imaging, Nuclear medicine, business, Radiofrequency coil
Abstract

International audience; Localization of regions with increased uptake of radiotracer in small-animal SPECT is greatly facilitated when using coregistration with anatomic images of the same animal. As MRI has several advantages compared with CT (soft-tissue contrast and lack of ionizing radiation) we developed a SPECT/low-field MRI hybrid device for small-animal imaging.Methods: A small-animal single-pinhole gamma-camera (pinhole, 1.5 mm in diameter and 12 cm in focal length) adjacent to a dedicated low-field (0.1 T) small MR imager (imaging volume, 10 x 10 x 6 cm(3)) was used. The animal was placed in a warmed nonmagnetic polymethyl methacrylate imaging cell for MR acquisition, which was followed immediately by SPECT after translation of the imaging cell from one modality to the other. 3-Dimensional T1-weighted sequences were used for MRI. Phantom studies enabled verification of a low attenuation (10%) for (99m)Tc and (201)Tl and a very slight increase in Compton scattering due to the radiofrequency coil and polymethyl methacrylate imaging cell.Results: SPECT/MRI data acquisition and image coregistration of selected examples using different radiotracers for lungs, kidneys, and brain were obtained in 3 nude mice with isotropic spatial resolutions of 0.5 x 0.5 x 0.5 mm(3) for MRI and 1 x 1 x 1 mm(3) for SPECT. The total acquisition time for combined SPECT and MRI lasted 1 h 45 min.Conclusion: A low-magnetic-field strength of 0.1 T is a simple and useful solution for a small-animal dual-imaging device combining pinhole SPECT with the adjacent MR imager.

Published
2008
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7. Magnetic resonance elastography compared with rotational rheometry for in vitro brain tissue viscoelasticity measurement

Author

André Constantinesco, Elodie Breton, Rémy Willinger, Jonathan Vappou, Philippe Choquet, Christian Goetz, Institut de Mécanique des Fluides et des Solides (IMFS), Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS), Service de Biophysique et Médecine Nucléaire, CHU Strasbourg-Université Louis Pasteur - Strasbourg I-Hôpital de Hautepierre [Strasbourg], and Remond, Yves

Subjects
Materials science, Rotation, Sus scrofa, Biophysics, Brain tissue, In Vitro Techniques, Viscoelasticity, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, 0302 clinical medicine, Nuclear magnetic resonance, Rheology, [SPI.MECA.BIOM] Engineering Sciences [physics]/Mechanics [physics.med-ph]/Biomechanics [physics.med-ph], Image Processing, Computer-Assisted, Animals, Radiology, Nuclear Medicine and imaging, Elasticity (economics), [PHYS.MECA.BIOM]Physics [physics]/Mechanics [physics]/Biomechanics [physics.med-ph], ComputingMilieux_MISCELLANEOUS, Radiological and Ultrasound Technology, Rheometry, Viscosity, [PHYS.MECA.BIOM] Physics [physics]/Mechanics [physics]/Biomechanics [physics.med-ph], Brain, [SPI.MECA.BIOM]Engineering Sciences [physics]/Mechanics [physics.med-ph]/Biomechanics [physics.med-ph], Elasticity, Magnetic resonance elastography, Homogeneous, Elasticity Imaging Techniques, Tissue stiffness, 030217 neurology & neurosurgery
Abstract

Magnetic resonance elastography (MRE) is an increasingly used method for non-invasive determination of tissue stiffness. MRE has shown its ability to measure in vivo elasticity or viscoelasticity depending on the chosen rheological model. However, few data exist on quantitative comparison of MRE with reference mechanical measurement techniques. MRE has only been validated on soft homogeneous gels under both Hookean elasticity and linear viscoelasticity assumptions, but comparison studies are lacking concerning viscoelastic properties of complex heterogeneous tissues. In this context, the present study aims at comparing an MRE-based method combined with a wave equation inversion algorithm to rotational rheometry. For this purpose, experiments are performed on in vitro porcine brain tissue. The dynamic behavior of shear storage (G') and loss (G ('')) moduli obtained by both rheometry and MRE at different frequency ranges is similar to that of linear viscoelastic properties of brain tissue found in other studies. This continuity between rheometry and MRE results consolidates the quantitative nature of values found by MRE in terms of viscoelastic parameters of soft heterogeneous tissues. Based on these results, the limits of MRE in terms of frequency range are also discussed.

Published
2007

8. Dynamic viscoelastic shear properties of soft matter by Magnetic Resonance Elastography using a low-field dedicated system

Author

Rémy Willinger, A. Constantinesco, Christian Goetz, Philippe Choquet, Elodie Breton, Jonathan Vappou, Institut de Mécanique des Fluides et des Solides (IMFS), Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS), and Krempff, Jean-Marie

Subjects
Shear waves, Materials science, Rheometer, Acoustics, 0206 medical engineering, [SPI.MECA.MEFL] Engineering Sciences [physics]/Mechanics [physics.med-ph]/Fluids mechanics [physics.class-ph], 02 engineering and technology, Viscoelasticity, 030218 nuclear medicine & medical imaging, [SPI.MECA.MEFL]Engineering Sciences [physics]/Mechanics [physics.med-ph]/Fluids mechanics [physics.class-ph], 03 medical and health sciences, 0302 clinical medicine, Optics, medicine, General Materials Science, Soft matter, medicine.diagnostic_test, business.industry, Mechanical Engineering, Resonance, Condensed Matter Physics, 020601 biomedical engineering, Magnetic resonance elastography, Mechanics of Materials, Elastography, business, Dynamic testing
Abstract

A magnetic resonance elastography (MRE) based method that consists in measuring dynamic viscoelastic parameters of soft matter by analysis of propagating shear waves at different frequencies is proposed. Dynamic shear tests were performed on soft gels with a dedicated magnetic resonance imaging system at low field (0.1T) and were compared with results obtained with a mechanical rotational rheometer. Storage and loss moduli were plotted against frequency with both methods and good agreement was found between their results in the shared frequency range. Therefore, it is shown that the described method could be a reliable and accessible tool for three-dimensional dynamic mechanical analysis on soft matter able to overcome dynamic range, sample dimensions and directional limitations of mechanical rheometers. Advantages and limits of the method are discussed.

Published
2006

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