1. Injection of calcium phosphate pastes: prediction of injection force and comparison with experiments
- Author
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Pierre Weiss, Monique A.V. Axelos, Julia Bosco, Rémi Deterre, Ahmed Fatimi, Jean-François Tassin, ProdInra, Migration, Laboratoire d'ingénierie osteo-articulaire et dentaire (LIOAD), Université de Nantes (UN)-IFR26-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut des Molécules et Matériaux du Mans (IMMM), Le Mans Université (UM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de génie des procédés - environnement - agroalimentaire (GEPEA), Institut Universitaire de Technologie - Nantes (IUT Nantes), Université de Nantes (UN)-Université de Nantes (UN)-Université de Nantes - UFR des Sciences et des Techniques (UN UFR ST), Université de Nantes (UN)-Université de Nantes (UN)-Institut Universitaire de Technologie Saint-Nazaire (IUT Saint-Nazaire), Université de Nantes (UN)-Ecole Polytechnique de l'Université de Nantes (EPUN), Université de Nantes (UN)-École nationale vétérinaire, agroalimentaire et de l'alimentation Nantes-Atlantique (ONIRIS)-Centre National de la Recherche Scientifique (CNRS)-Université Bretagne Loire (UBL)-IMT Atlantique (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Institut Universitaire de Technologie - La Roche-sur-Yon (IUT La Roche-sur-Yon), Université de Nantes (UN), Unité de recherche sur les Biopolymères, Interactions Assemblages (BIA), Institut National de la Recherche Agronomique (INRA), Ecole de Technologie Supérieure, Partenaires INRAE, LUNAM Université [Nantes Angers Le Mans], Polymères, colloïdes, interfaces (PCI), Le Mans Université (UM), Université du Maine [Le Mans - Laval], Institut Universitaire de Technologie, and Université de Nantes (UN)-Ecole Nationale Vétérinaire, Agroalimentaire et de l'alimentation Nantes-Atlantique (ONIRIS)-Centre National de la Recherche Scientifique (CNRS)-Université Bretagne Loire (UBL)-IMT Atlantique Bretagne-Pays de la Loire (IMT Atlantique)
- Subjects
Calcium Phosphates ,cement ,thermogelation ,Materials science ,Capillary action ,[SPI.GPROC] Engineering Sciences [physics]/Chemical and Process Engineering ,ceramic ,rheological property ,Biomedical Engineering ,Biophysics ,Bioengineering ,Biocompatible Materials ,02 engineering and technology ,system ,010402 general chemistry ,01 natural sciences ,Biomaterials ,Ointments ,Viscosity ,Hypromellose Derivatives ,Rheology ,[SDV.IDA]Life Sciences [q-bio]/Food engineering ,Newtonian fluid ,methylcellulose ,suspension ,[SPI.GPROC]Engineering Sciences [physics]/Chemical and Process Engineering ,Composite material ,Suspension (vehicle) ,[SDV.IDA] Life Sciences [q-bio]/Food engineering ,021001 nanoscience & nanotechnology ,0104 chemical sciences ,Volumetric flow rate ,Shear rate ,hydroxypropylmethylcellulose ,Microscopy, Electron, Scanning ,injectable bone substitute ,Extrusion ,acid ,0210 nano-technology - Abstract
Fatimi, Ahmed Tassin, Jean-Francois Bosco, Julia Deterre, Remi Axelos, Monique A. V. Weiss, Pierre 39 SPRINGER ANG CY, 1994, JOURNAL OF RHEOLOGY, V38, P85 IGER K, 1989, KAUTSCHUK GUMMI KUNSTSTOFFE, V42, P273; International audience; Calcium phosphate ceramics suspensions (ICPCS) are used in bone and dental surgery as injectable bone substitutes. This ICPCS biomaterial associates biphasic calcium phosphate (BCP) granules with hydroxypropylmethylcellulose (HPMC) polymer. Different ICPCS were prepared and their rheological properties were evaluated in parallel disks geometry as a function of the BCP weight ratio (35, 40, 45 and 50 %). The suspensions show a strongly increased viscosity as compared to the suspending fluid and the high shear rate part of the flow curve can be fitted with a power law model (Ostwald-de Waele model). The fitting parameters depend on the composition of the suspension. A simple device has been used to characterize extrusion of the paste using a disposable syringe fitted with a needle. The injection pressure of four ICPCS formulations was studied under various conditions (needle length and radius and volumetric flow rate), yielding an important set of data. A theoretical approach based on the capillary flow of non-Newtonian fluids was used to predict the necessary pressure for injection, on the basis of flow curves and extrusion conditions. The extrusion pressure calculated from rheological data shows a quantitative agreement with the experimental one for model fluids (Newtonian and HPMC solution) but also for the suspension, when needles with sufficiently large diameters as compared to the size of particles, are used. Depletion and possibly wall slip is encountered in the suspensions when narrower diameters are used, so that the injection pressure is less than that anticipated. However a constant proportionality factor exists between theory and injection experiments. The approach developed in this study can be used to correlate the rheological parameters to the necessary pressure for injection and defines the pertinent experimental conditions to obtain a quantitative agreement between theory and experiments.
- Published
- 2012
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