1. HBV Infection Status and the Risk of Cholangiocarcinoma in Asia: A Meta-Analysis.
- Author
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Zhang, Hao, Zhu, Biqing, Zhang, He, Liang, Jianxin, and Zeng, Wenting
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CHI-squared test , *CONFIDENCE intervals , *HEPATITIS B , *MEDICAL databases , *INFORMATION storage & retrieval systems , *MEDLINE , *META-analysis , *ONLINE information services , *PROBABILITY theory , *RESEARCH funding , *SYSTEMATIC reviews , *CHOLANGIOCARCINOMA , *DISEASE incidence , *DATA analysis software , *DESCRIPTIVE statistics , *ODDS ratio , *DISEASE complications , *DISEASE risk factors - Abstract
Background. The inconsistent finding was between hepatitis B virus (HBV) infections and cholangiocarcinoma (CCA). This meta-analysis is to explore this relationship in Asia. Methods. A literature search was performed using PubMed, Web of Science, and Cochrane Library to October 30, 2015. Pooled incidence rate and OR with 95% CI were calculated using STATA 11.0. Results. Thirty-nine studies were included. The pooled incidence rate of CCA patients with HBV infection was 31% (95% CI 22%–39%). The pooled OR showed increased risk of CCA incidence with HBV infection (OR = 2.72, 95% CI 1.90–3.88), especially in ICC (OR = 3.184, 95% CI 2.356–4.302), while it showed no risk in ECC (OR = 1.407, 95% CI 0.925–2.141). Also, the pooled OR showed increased risk of ICC and ECC incidence (OR = 6.857, 95% CI 4.421–10.633 and OR = 1.740, 95% CI 1.260–2.404) in patients with HBsAg+/HBcAb+. The pooled OR showed increased risk of ICC incidence (OR = 1.410, 95% CI 1.095–1.816) in patients with HBsAg−/HBcAb+. Conclusion. It is suggested that HBV infection is associated with an increased risk of CCA in Asia. Two HBV infection models (HBsAg+/HBcAb+ and HBsAg−/HBcAb+) increase the risk of CCA, and patients with HBsAg−/HBcAb+ also had a risk of ICC. This trial is registered with PROSPERO
CRD42015029264 . [ABSTRACT FROM AUTHOR]- Published
- 2016
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