1. Proton pump inhibitors reduce breast cancer risk in gastric ulcer patients: A population‐based cohort study
- Author
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Fung-Chang Sung, Dah-Ching Ding, Jen-Hung Wang, Shinn Zong Lin, and Weishan Chen
- Subjects
medicine.medical_specialty ,Breast Neoplasms ,030218 nuclear medicine & medical imaging ,Cohort Studies ,03 medical and health sciences ,Population based cohort ,0302 clinical medicine ,Breast cancer ,Internal medicine ,Internal Medicine ,Humans ,Medicine ,Stomach Ulcer ,business.industry ,Incidence ,Incidence (epidemiology) ,Hazard ratio ,Proton Pump Inhibitors ,medicine.disease ,Oncology ,030220 oncology & carcinogenesis ,Peptic ulcer ,Cohort ,Female ,Surgery ,business ,Cohort study - Abstract
We aim to evaluate breast cancer risk relating to PPIs usage in women with peptic ulcer. From 2000 to 2013, incidence rates of breast cancer were compared between the two cohorts (with or without PPIs). Each study cohort consisted of 4838 women. The incidence density rate of breast cancer in the PPI cohort was 0.29 that in the comparison cohort (10.0 vs 31.6 per 10 000 person-years), with an adjusted HR (hazard ratio) of 0.32 (95% CI = 0.20-0.49) for the PPI cohort. In conclusion, the medication of PPIs is associated with reduced breast cancer risk for women with gastric ulcer.
- Published
- 2020