1. Fluorescent 10B embedded nanodiamonds as 10B delivery agent for boron neutron capture therapy
- Author
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Bo-Rong Lin, Srinivasu Kunuku, Tzung-Yuang Chen, Yu-Jen Chang, Li-Chuan Liao, Chien-Hsu Chen, Tung-Yuan Hsiao, Hung-Kai Yu, Huan Niu, and Chien-Ping Lee
- Subjects
inorganic chemicals ,Boron Delivery Agent ,Materials science ,Acoustics and Ultrasonics ,Annealing (metallurgy) ,chemistry.chemical_element ,Nanotechnology ,02 engineering and technology ,Isotopes of boron ,021001 nanoscience & nanotechnology ,Condensed Matter Physics ,Fluorescence ,Neutron therapy ,Surfaces, Coatings and Films ,Electronic, Optical and Magnetic Materials ,03 medical and health sciences ,Neutron capture ,0302 clinical medicine ,Ion implantation ,chemistry ,030220 oncology & carcinogenesis ,0210 nano-technology ,Boron - Abstract
Boron neutron capture therapy is a powerful anti-cancer treatment, the success of which depends heavily on the boron delivery agent. Enabling the real-time tracing of delivery agents as they move through the body is crucial to the further development of boron neutron therapy. In this study, we fabricate highly bio-compatible boron-10 embedded nanodiamonds using physical ion implantation in conjunction with a two-step annealing process. The red fluorescence of the nanodiamonds allows their use in fluorescence microscopy and in vivo imaging systems, thereby making it possible to conduct tracking in real time. The proposed fluorescent boron-10 embedded nanodiamonds, combining optical visibility and boron-10 transport capability, are a promising boron delivery agent suitable for a wide range of biomedical applications.
- Published
- 2019