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Your search keyword '"Rhoads, Kristoffer W."' showing total 4 results
Start Over Author "Rhoads, Kristoffer W." Publisher ios press
4 results on '"Rhoads, Kristoffer W."'

3. Statin Users Without an APOE-ℇ4 Allele have Increased Insulin Resistance.

Author

VanFossen, Brian T., Watson, G. Stennis, Baker, Laura D., Rhoads, Kristoffer W., Cholerton, Brenna A., Reger, Mark A., Plymate, Stephen R., Schellenberg, Gerald, and Craft, Suzanne

Subjects
ALZHEIMER'S disease, STATINS (Cardiovascular agents), APOLIPOPROTEIN E, INSULIN resistance, HOMEOSTASIS, DIABETES, INSULIN
Abstract

The present study examined the relationships among statin use, APOE genotype, and insulin resistance as measured by the homeostasis model assessment of insulin resistance (HOMA-IR) in healthy older adults. APOE ℇ4- (i.e., not having an ℇ4 allele) statin users had higher HOMA-IR values compared with ℇ4+/statin users (p=0.0169), and with non-users who were ℇ4- (p=0.0003) or ℇ4+ (p=0.0006). These results suggest that statin use may modulate insulin levels for individuals without an APOE ℇ4 allele. [ABSTRACT FROM AUTHOR]

Published
2010
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4. Statin users without an APOE-epsilon4 allele have increased insulin resistance.

Author

VanFossen BT, Watson GS, Baker LD, Rhoads KW, Cholerton BA, Reger MA, Plymate SR, Schellenberg G, and Craft S

Subjects
Aged, Alzheimer Disease epidemiology, Alzheimer Disease genetics, Dementia epidemiology, Dementia genetics, Diabetes Mellitus epidemiology, Female, Genotype, Homeostasis, Humans, Male, Prevalence, Anticholesteremic Agents therapeutic use, Apolipoprotein E4 genetics, Hydroxymethylglutaryl-CoA Reductase Inhibitors therapeutic use, Hypercholesterolemia drug therapy, Hypercholesterolemia epidemiology, Hypercholesterolemia genetics, Metabolic Syndrome epidemiology
Abstract

The present study examined the relationships among statin use, APOE genotype, and insulin resistance as measured by the homeostasis model assessment of insulin resistance (HOMA-IR) in healthy older adults. APOE epsilon4- (i.e., not having an epsilon4 allele) statin users had higher HOMA-IR values compared with epsilon4+/statin users (p=0.0169), and with non-users who were epsilon4- (p=0.0003) or epsilon4+ (p=0.0006). These results suggest that statin use may modulate insulin levels for individuals without an APOE epsilon4 allele.

Published
2010
Full Text
View/download PDF

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