1. FVIII/VWF ratio is not a reliable predictor of VWD in children.
- Author
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Branchford BR, Ruegg K, Villalobos-Menuey E, Jacobson LJ, Di Paola JA, and Manco-Johnson M
- Subjects
- Adult, Blood Coagulation Tests, Case-Control Studies, Child, Child, Preschool, Enzyme-Linked Immunosorbent Assay, Female, Follow-Up Studies, Humans, Infant, Male, Middle Aged, Prognosis, Young Adult, von Willebrand Disease, Type 1 blood, Biomarkers blood, Factor VIII analysis, von Willebrand Disease, Type 1 diagnosis, von Willebrand Factor analysis
- Abstract
Adults with von Willebrand Disease (VWD) are known to have a ratio of factor VIII activity (FVIII:C) to von Willebrand factor antigen (VWF:Ag) greater than 1. We, however, noted healthy children with ratios that are unexpectedly high. Though the FVIII:C/VWF:Ag ratio differs significantly between healthy children and VWD patients in some age groups, the substantial overlap of observed ranges suggests that a ratio threshold-based screening approach alone cannot reliably discriminate between these groups. The diagnostic performance of this ratio is poor for VWD in children, which may decrease its value as a screening tool in the pediatric population., (© 2013 Wiley Periodicals, Inc.)
- Published
- 2014
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