1. High-Throughput Flow Cytometry
- Author
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Marius Olah, Anna Waller, Susan M. Young, Sean M. Biggs, Larry A. Sklar, Bruce S. Edwards, Cristian Bologa, Peter C. Simons, Eric R. Prossnitz, and Tudor I. Oprea
- Subjects
Cell physiology ,Business process discovery ,Molecular interactions ,Virtual screening ,Disk formatting ,medicine.diagnostic_test ,Computer science ,medicine ,Computational biology ,Throughput (business) ,Overall efficiency ,Flow cytometry - Abstract
This article describes the creation of a discovery team in an academic environment. The team is specifically structured to perform four integrated activities: characterizing membrane protein, formatting the materials for analysis of cell physiology and molecular interactions, performing screens of small-molecule activity on a novel high-throughput flow cytometric instrument platform, and integrating virtual screening with activity screening. These activities improve the overall efficiency of the discovery process. Keywords: discovery team; virtual screening; cell physiology; molecular interactions
- Published
- 2010
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