1. In situ magnesium calcium phosphate cements formation: From one pot powders precursors synthesis to in vitro investigations
- Author
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M.A. Goldberg, P.A. Krohicheva, A.S. Fomin, D.R. Khairutdinova, O.S. Antonova, A.S. Baikin, V.V. Smirnov, A.A. Fomina, A.V. Leonov, I.V. Mikheev, N.S. Sergeeva, S.A. Akhmedova, S.M. Barinov, and V.S. Komlev
- Subjects
Magnesium calcium phosphate cement ,Stanfieldite ,Whitlockite ,Newberyite ,Brushite ,In vitro investigations ,Materials of engineering and construction. Mechanics of materials ,TA401-492 ,Biology (General) ,QH301-705.5 - Abstract
Calcium phosphate cements are of great interest for researchers and their applications in medical practice expanded. Nevertheless, they have a number of drawbacks including the insufficient level of mechanical properties and low degradation rate. Struvite (MgNH4PO4) -based cements, which grew in popularity in recent years, despite their neutral pH and acceptable mechanical performance, release undesirable NH4+ ions during their resorption. This issue could be avoided by replacement of ammonia ions in the cement liquid with sodium, however, such cements have a pH values of 9–10, leading to cytotoxicity.Thus, the main goal of this investigation is to optimize the composition of cements to achieve the combination of desirable properties: neutral pH, sufficient mechanical properties, and the absence of cytotoxicity, applying Na2HPO4-based cement liquid. For this purpose, cement powders precursors in the CaO–MgO–P2O5 system were synthesized by one-pot process in a wide composition range, and their properties were investigated.The optimal performance was observed for the cements with (Ca + Mg)/P ratio of 1.67, which are characterized by newberyite phase formation during setting reaction, pH values close to 7, sufficient compressive strength up to 22 ± 3 MPa (for 20 mol.% of Mg), dense microstructure and adequate matrix properties of the surface. This set of features make those materials promising candidates for medical applications.
- Published
- 2020
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