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Your search keyword '"Pedrol, Enric"' showing total 5 results
Start Over Author "Pedrol, Enric" Publisher lippincott williams & wilkins, wk health
5 results on '"Pedrol, Enric"'

1. Effect of genetic variants of CCR2 and CCL2 on the natural history of HIV-1 infection: CCL2-2518GG is overrepresented in a Cohort of Spanish HIV-1-infected subjects

Author

Vilades, Consuelo, Broch, Montserrat, Plana, Montserrat, Domingo, Pere, Alonso-Villaverde, Carlos, and Pedrol, Enric

Subjects
HIV infection -- Genetic aspects, HIV infection -- Natural history, HIV infection -- Risk factors, Genetic variation -- Analysis, Health
Abstract

A study was carried out to determine whether functionally active CCR2 and CCL2 genetic variants influence the risk of infection and disease progression in a cohort of white Spaniards. The distribution of CCL2 alleles showed no significant differences between groups but HIV-1-infected individuals had a significantly higher prevalence of the variant homozygous CCL2 GG genotype as compared to EUs.

Published
2007

2. Polymorphism of RANTES chemokine gene promoter is not associated with long-term nonprogressive HIV-1 infection of more than 16 years

Author

Vidal, Francesc, Peraire, Joaquin, Fontanet, Angels, Domingo, Pere, Broch, Monteserrat, Dalmau, David, Cairo, Mireia, Pedrol, Enric, Deig, Elisabeth, Montero, Milagros, Vilades, Consuelo, Knobel, Hernando, Gutierrez, Cristina, Sambeat, M. Antonio, Sirvent, Joan Josep, and Richart, Cristobal

Subjects
HIV infection -- Genetic aspects, Single nucleotide polymorphisms -- Research, Chemokines -- Research, Health
Abstract

A cross-sectional genetic association case-control study is conducted to examine the association of the polymorphisms of the RANTES chemokine gene promoter with the long-term nonprogressive HIV-1 infection. The analysis suggests that the single nucleotide polymorphisms (Snips) in the RANTES associated with the long-term nonprogressors (LNTPs) cannot exceed more than sixteen years.

Published
2006

3. Spanish HIV-1-infected long-term nonprogressors of more than 15 years have an increased frequency of the CX3CR1 249I variant allele

Author

Vidal, Francesc, Vilades, Consuedo, Domingo, Pere, Broch, Montserrat, Pedrol, Enric, Dalmau, David, Knobel, Hernando, Peraire, Joaquim, Gutierrez, Cristina, Sambeat, Antonia, Fontanet, Angels, Dieg, Elisabeth, Cairo, Mireia, Montero, Milagros, Richart, Cristobal, and Mallal, Simon

Subjects
Allelomorphism -- Research, Genetic variation -- Research, HIV infection -- Research, Genetic research, Health
Abstract

A study was conducted to determine whether functionally active CX3CR1 genetic variants are associated with long-term nonprogressive (LTNP) infection of less than 15 years in HIV-1 infected Spanish patients. The result shows that CX3CR1 249I variant allele is more frequent in Spanish HIV-1 infected LTNPs of less than 15 years, and the effect is independent of the presence of the CCR5(delta)32 allele.

Published
2005

4. Upregulatory mechanisms compensate for mitochondrial DNA depletion in asymptomatic individuals receiving stavudine plus didnosine

Author

Miro, Oscar, Marinez, Esteban, Giralt, Marta, Vilarroya, Francesc, Casademont, Jordi, Concepcion, Marisa Rodriguez de la, Lopez, Sonia, Gsttsbou, Gloria, Pedrol, Enric, Gatell, Josep M., and Cardellach, Francesc

Subjects
Stavudine -- Physiological aspects, Stavudine -- Chemical properties, Mitochondrial DNA -- Research, Antiviral agents -- Analysis, Antiviral agents -- Physiological aspects, Health
Abstract

The certainty that the homeostatic mechanisms are able to compensate for this mtDNA depletion in patients receiving stavudine plus didnosine(d4T+ ddI), an antiretroviral combination with great in vitro and in vivo capacity to decrease mtDNA is determined. The study concludes that treatment with ddT=ddI is associated with decreased mitochondrial mass and mtDNA content but that cytochrome c oxidase subnit II (COX-II) expression and COX activity remain unaltered.

Published
2004

5. Lack of association of SDF-1 3'A variant allele with long-term nonprogressive HIV-1 infection is extended beyond 16 years

Author

Vidal, Francesc, Domingo, Pere, Knobel, Hernando, Dalmau, David, Sambeat, Antonia, Peraire, Joaquim, Broch, Montserrat, Pedrol, Enric, Vilades, Consuelo, Gutierrez, Cristina, and Richart, Cristobal

Subjects
Spaniards -- Health aspects, HIV infection -- Research, HIV infection -- Development and progression, Health
Abstract

The frequency of the SDF-1 3'A allelic variant in a cohort of white Spaniards made up of Human Immunodeficiency Virus (HIV)-1-infected long-term nonprogressors (LTNPs) older than 16 years of age, HIV-1-infected usual progressors and a group of healthy controls are studied. The results indicate that the SDF-1 3' A polymorphism is not a determinant of LTNP in HIV-1-infected Spanish patients.

Published
2005

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