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B Introduction: b The Surviving Sepsis Guidelines recommend initiating fixed-dose vasopressin (AVP) for patients with persistent hypotension despite norepinephrine (NE), but it is unclear if this dosing strategy is sufficient in obese patients. B Methods: b An interim analysis of a multicenter, retrospective cohort study was conducted to assess the impact of fixed-dose AVP (0.03 or 0.04 units/min) on mortality in obese patients with septic shock compared to non-obese patients. B Conclusions: b Compared to non-obese patients, obese patients with septic shock receiving fixed-dose AVP had a higher incidence of mortality. [Extracted from the article]

The medical center experienced 8 wrong site/procedure/patient events between April 2008 and January 2010. A common cause analysis (CCA) was conducted on all 8 events to determine the causal factors of these events. After a sentinel event is identified, the medical center conducts a root cause analysis (RCA) within 45 days of the event. A CCA helps recognize trends and establish themes identified from each RCA. The CCA revealed that there were 22 occurrences of failure modes noted in the category of Rules, Policies, and Procedures and 17 failure modes present in the category of Human Factors: Scheduling and Fatigue. A multidisciplinary team was assembled to confirm the failure modes identified in the CCA and to develop processes to address these failure modes. No further wrong site, procedure, or person events have occurred over the last year. [ABSTRACT FROM PUBLISHER]

Objectives: To investigate associations between health-related behaviors as measured using the Brain Care Score (BCS) and neuroimaging markers of white matter injury., Methods: This prospective cohort study in the UK Biobank assessed the BCS, a novel tool designed to empower patients to address 12 dementia and stroke risk factors. The BCS ranges from 0 to 21, with higher scores suggesting better brain care. Outcomes included white matter hyperintensities (WMH) volume, fractional anisotropy (FA), and mean diffusivity (MD) obtained during 2 imaging assessments, as well as their progression between assessments, using multivariable linear regression adjusted for age and sex., Results: We included 34,509 participants (average age 55 years, 53% female) with no stroke or dementia history. At first and repeat imaging assessments, every 5-point increase in baseline BCS was linked to significantly lower WMH volumes (25% 95% CI [23%-27%] first, 33% [27%-39%] repeat) and higher FA (18% [16%-20%] first, 22% [15%-28%] repeat), with a decrease in MD (9% [7%-11%] first, 10% [4%-16%] repeat). In addition, a higher baseline BCS was associated with a 10% [3%-17%] reduction in WMH progression and FA decline over time., Discussion: This study extends the impact of the BCS to neuroimaging markers of clinically silent cerebrovascular disease. Our results suggest that improving one's BCS could be a valuable intervention to prevent early brain health decline.